PMID- 10319580
OWN - NLM
STAT- MEDLINE
DCOM- 19990608
LR  - 20221207
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 3
DP  - 1999
TI  - Association of diffuse panbronchiolitis with microsatellite polymorphism of the 
      human interleukin 8 (IL-8) gene.
PG  - 169-72
AB  - Diffuse panbronchiolitis (DPB) is a distinctive chronic inflammatory lung disease 
      predominantly found in Asian populations. Although its etiology is unknown, DPB 
      is considered to be a multifactorial disease of whose susceptibility is 
      determined by genetic predisposition unique to Asians. We and others have 
      previously reported that the B*5401 allele of the human leukocyte antigen (HLA)-B 
      gene or a closely linked gene in the HLA region on 6p21.3 is one of the major 
      genetic factors in susceptibility to this disease. However, the association with 
      B*5401 is not absolute and the contribution of other genetic or environmental 
      factors should also be considered. Here, four candidate genes that are postulated 
      to play a role in the pathophysiology of DPB, namely, RON-kinase, CYP3A4, 
      motilin, and interleukin (IL)-8, were chosen, and association studies between 
      microsatellite markers at these loci and DPB were conducted. We demonstrated the 
      presence of a specific allele at the IL-8 locus was associated with the disease 
      (c2 = 9.13; P = 0.0025; corrected P [Pc] < 0.05). Although further studies are 
      needed to examine whether neutrophil accumulation in the airways of patients with 
      DPB is controlled by a possible genetic variation of IL-8 or other chemokine 
      genes located in the region 4q12-q13, our data suggest that genes other than 
      those of the HLA system may also contribute to a genetic predisposition to DPB.
FAU - Emi, M
AU  - Emi M
AD  - Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan. 
      memi@nms.ac.jp
FAU - Keicho, N
AU  - Keicho N
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Katsumata, H
AU  - Katsumata H
FAU - Souma, S
AU  - Souma S
FAU - Nakata, K
AU  - Nakata K
FAU - Taguchi, Y
AU  - Taguchi Y
FAU - Ohishi, N
AU  - Ohishi N
FAU - Azuma, A
AU  - Azuma A
FAU - Kudoh, S
AU  - Kudoh S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Cell Surface)
RN  - 52906-92-0 (Motilin)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.14.1 (CYP3A protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP3A)
RN  - EC 1.14.14.55 (CYP3A4 protein, human)
RN  - EC 2.7.10.1 (RON protein)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Asian People/*genetics
MH  - Bronchiolitis/*genetics
MH  - Chromosomes, Human, Pair 6
MH  - Cytochrome P-450 CYP3A
MH  - Cytochrome P-450 Enzyme System/genetics
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-8/*genetics
MH  - Japan
MH  - *Microsatellite Repeats
MH  - Mixed Function Oxygenases/genetics
MH  - Motilin/genetics
MH  - Multifactorial Inheritance
MH  - *Polymorphism, Genetic
MH  - Receptor Protein-Tyrosine Kinases/genetics
MH  - Receptors, Cell Surface/genetics
EDAT- 1999/05/13 00:00
MHDA- 1999/05/13 00:01
CRDT- 1999/05/13 00:00
PHST- 1999/05/13 00:00 [pubmed]
PHST- 1999/05/13 00:01 [medline]
PHST- 1999/05/13 00:00 [entrez]
AID - 10.1007/s100380050135 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(3):169-72. doi: 10.1007/s100380050135.