PMID- 10322955
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20161124
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 13
IP  - 4
DP  - 1997 Nov
TI  - [Studies of mechanism of erythrocyte deformability injury during hypobaric 
      hypoxia in rats].
PG  - 306-8
AB  - Rats were randomized into sea level group and hyoxic group. Erythrocyte 
      filtration index (IF), mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      concentration (MCHC), erythrocyte [pH]i, [Mg2-]i, [Ca2+]i and [K+]i/[Na+]i were 
      investigated in our studies. The results were as follows: 1. IF was increared in 
      hypoxic group (0.234 +/- 0.060) 2. [Ca2+]i of hypoxic group (7.02 +/- 1.66) was 
      evidently increased and correlated with its IF (r = 0.7386, P < 0.01), but 
      [Mg2+]i had no obvious changes, [K+]i/ [Na+]i ratio of hypoxic group was reduced 
      and negatively correlated with IF (r = -0.3957, P < 0.05), meanwhile, [pH] of 
      hypoxic group increased evidently. 3. There was no statistic difference between 
      MCHC of hypoxic and sea level group, but MCV of hypoxic group increased. These 
      findings suggest that the changes of [Ca2+]i, [K+]i/[Na+]i ratio, [pH]i and MCV 
      may play important role in erythrocyte deformability injury during hypoxia.
FAU - Liang, W
AU  - Liang W
AD  - Department of Pathophysiology, Third Military medical University, Chongqing.
FAU - Luo, D
AU  - Luo D
FAU - Gao, Y
AU  - Gao Y
FAU - Zhang, G
AU  - Zhang G
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Erythrocyte Deformability/*physiology
MH  - Erythrocyte Indices
MH  - Female
MH  - Hypoxia/*blood/etiology
MH  - Male
MH  - Potassium/metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Sodium/metabolism
EDAT- 1999/05/14 00:00
MHDA- 1999/05/14 00:01
CRDT- 1999/05/14 00:00
PHST- 1999/05/14 00:00 [pubmed]
PHST- 1999/05/14 00:01 [medline]
PHST- 1999/05/14 00:00 [entrez]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):306-8.