PMID- 10323025
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20140625
VI  - 11
IP  - 12
DP  - 1997 Dec
TI  - [Study on HPV infection and p53 protein expression in laryngeal carcinoma].
PG  - 546-9
AB  - In order to evaluate the role of human papillomavirus (HPV) infection and p53 
      protein expression in laryngeal squamous cell carcinoma (LSCC), the in situ 
      hybridization and the labelled streptavidin biotin (LSAB) immunohistochemical 
      method were used to detect the presence of HPV genomes 6B, 11, 16, 18 and 
      expression of p53 protein respectively in 44 specimens of LSCC. And 16 specimens 
      of laryngeal polyp were selected as controls. RESULTS: 1. HPV genomes 16/18 were 
      detected in 19 (43.2%) of 44 LSCCs and in 2 (12.5%) of 16 laryngeal polyps (P < 
      0.05). 2.25 (56.9%) of 44 specimens of LSCC were p53 protein positive whereas the 
      laryngeal polyps were all p53 negative. 3. 12 (63.2%) of 19 HPV 16/18 
      DNA-positive specimens of LSCC showed p53 protein expression and 12 (48%) of 25 
      p53 protein positive specimens of LSCC showed HPV 16/18 infection. CONCLUSION: 
      Expression of p53 protein and infection of HPV 16, 18 may play a role in 
      carcinogenesis of LSCC, respectively or simultaneously.
FAU - Qin, Z
AU  - Qin Z
AD  - First Affiliated Hospital, Henan Medical University, Zhengzhou.
FAU - Dong, M
AU  - Dong M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (DNA, Viral)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/*virology
MH  - DNA, Viral/analysis
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/metabolism/*virology
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae/*isolation & purification
MH  - *Papillomavirus Infections
MH  - Tumor Suppressor Protein p53/*biosynthesis
MH  - *Tumor Virus Infections
EDAT- 1999/05/14 00:00
MHDA- 1999/05/14 00:01
CRDT- 1999/05/14 00:00
PHST- 1999/05/14 00:00 [pubmed]
PHST- 1999/05/14 00:01 [medline]
PHST- 1999/05/14 00:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1997 Dec;11(12):546-9.