PMID- 10323033
OWN - NLM
STAT- MEDLINE
DCOM- 19990611
LR  - 20140625
VI  - 11
IP  - 8
DP  - 1997 Aug
TI  - [Significance of p16 and C-myc expression in the laryngeal squamous cell 
      carcinoma].
PG  - 352-5
AB  - OBJECTIVE: To study the clinical significance of p16 and C-myc expression in the 
      laryngeal squamous cell carcinoma (LSCC). METHOD: Immunohisto-chemical detection 
      of p16 proteins and C-myc proteins, in 47 cases of LSCC and 6 cases of normal 
      tissues from the larynx, were conducted in paraffin-embeded sections. RESULTS: No 
      staining was found in 6 cases of normal tissue; The positive expression of p16 
      and C-myc proteins expression rates did not correlate with sex, age and position 
      of the tumors (P > 0.05); but related to the staging and grade of LSCC (P < 
      0.05). The expression of C-myc proteins were higher in the case with lymph nodal 
      metastasis than that without lymph nodal metastasis (P < 0.05). CONCLUSION: The 
      expression of p16 and C-myc protein may play an important role in the development 
      of LSCC, and may be a new indicator to assess the prognosis of LSCC.
FAU - Peng, J
AU  - Peng J
AD  - Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University of Medical Science, Guangzhou.
FAU - Zeng, Y
AU  - Zeng Y
FAU - Xu, Y
AU  - Xu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Cyclin-Dependent Kinase Inhibitor p16/*biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-myc/*biosynthesis
EDAT- 1997/08/01 00:00
MHDA- 1999/05/14 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1999/05/14 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1997 Aug;11(8):352-5.