PMID- 10323067
OWN - NLM
STAT- MEDLINE
DCOM- 19990519
LR  - 20161124
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 140
IP  - 10
DP  - 1999 Mar 7
TI  - [Intravenous adenosine infusion in the assessment of coronary flow reserve in 
      hypertension. Transesophageal Doppler echocardiographic study].
PG  - 523-7
AB  - In hypertensive patients with normal coronary angiography typical chest pain may 
      be caused by microvascular coronary artery disease. This can be confirmed by 
      decreased coronary flow reserve (CFR). Adenosine test with transesophageal 
      echocardiography was chosen for the measurement of CFR. There are only few 
      reports in the literature which utilized this test. The purpose of this study was 
      primarily to further elucidate some technical aspects and to evaluate CFR in 
      hypertensive patients with angina, positive stress test and normal coronary 
      angiography. Out of 12 such consecutive patients the adenosine test was 
      successful in 11. Adenosine was given in 140 mcg/kg/min dose as a 5 minute 
      continuous infusion. Mean coronary flow velocity (Vm), CFR, baseline coronary 
      flow resistance (CVR) and maximal coronary dilation (CRR) in the left anterior 
      descending artery were measured and calculated by multiplane transesophageal 
      Doppler echocardiography. There was a 43% increase of heart rate and a 7% 
      decrease of systolic blood pressure. Baseline Vm was 36 +/- 16 cm/s, CFR 2.4 +/- 
      0.4, baseline CVR was 2.8 +/- 1.0 mmHg/s/an, CRR was 2.4 +/- 0.4. Left main 
      coronary dimension did not change. There was no important side effect. While 
      baseline Vm was similar to normal values in the literature, CFR and CRR were 
      decreased compared to normals. There was no correlation between baseline Vm or 
      heart rate and CFR but a direct correlation was found between baseline CVR and 
      CRR (r = 0.54). Peak effect of adenosine was achieved at 3-5 minutes. 
      CONCLUSIONS: Adenosine-TEE infusion test is a safe and easy to perform technique 
      to assess CFR in hypertensive patients. In hypertensive patients with documented 
      ischemia and normal coronary angiography the coronary flow reserve is decreased.
FAU - Lengyel, M
AU  - Lengyel M
AD  - Gottsegen Gyorgy Orszagos Kardiologiai Intezet, Budapest.
FAU - Borbas, S
AU  - Borbas S
LA  - hun
PT  - Journal Article
PT  - Review
TT  - Intravenas adenozin a coronaria aramlasi rezerv kimutatasara hypertoniaban. 
      Transoesophagealis Doppler-echokardiografias vizsgalat.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - *Adenosine/administration & dosage
MH  - Adult
MH  - Coronary Circulation/*physiology
MH  - *Echocardiography, Transesophageal
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension/diagnostic imaging/*physiopathology
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
RF  - 45
EDAT- 1999/05/14 00:00
MHDA- 1999/05/14 00:01
CRDT- 1999/05/14 00:00
PHST- 1999/05/14 00:00 [pubmed]
PHST- 1999/05/14 00:01 [medline]
PHST- 1999/05/14 00:00 [entrez]
PST - ppublish
SO  - Orv Hetil. 1999 Mar 7;140(10):523-7.