PMID- 10325441
OWN - NLM
STAT- MEDLINE
DCOM- 19990824
LR  - 20171101
IS  - 0006-3126 (Print)
IS  - 0006-3126 (Linking)
VI  - 75
IP  - 6
DP  - 1999
TI  - Efficacy of anti-tumor necrosis factor-alpha antibody as an adjunctive therapy in 
      experimental Escherichia coli meningitis in the newborn piglet.
PG  - 377-87
AB  - This study was done to evaluate the efficacy of anti-tumor necrosis factor alpha 
      (anti-TNF-alpha) antibody as an adjunctive therapy in neonatal bacterial 
      meningitis. Newborn piglets were divided into three groups: 8 in the control 
      group, 13 in the meningitis group (MG), and 10 in the meningitis with 
      anti-TNF-alpha antibody group (AG). Meningitis was induced by intracisternal 
      injection of 10(8) colony-forming units of Escherichia coli in 100 microl of 
      saline. In the AG, 200 microl of anti-TNF-alpha antibody was also given 
      intracisternally. In the AG, the elevated cerebrospinal fluid TNF-alpha level 
      observed in the MG was completely abolished, and increased intracranial pressure, 
      hypoglycorrhachia, and CSF pleocytosis observed in the MG were downmodulated. But 
      blood, brain, and CSF lactate levels remained elevated in both MG and AG. 
      Increased brain cell membrane lipid peroxidation products and decreased 
      Na+,K+-ATPase activity observed in the MG were not attenuated in the AG. These 
      results indicate that anti-TNF-alpha antibody was not particularly effective as 
      an adjunctive therapy in attenuating acute inflammatory responses and 
      ameliorating brain damage in neonatal bacterial meningitis.
FAU - Park, W S
AU  - Park WS
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University College 
      of Medicine, Seoul, Korea.
FAU - Chang, Y S
AU  - Chang YS
FAU - Ko, S Y
AU  - Ko SY
FAU - Kang, M J
AU  - Kang MJ
FAU - Han, J M
AU  - Han JM
FAU - Lee, M
AU  - Lee M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Biol Neonate
JT  - Biology of the neonate
JID - 0247551
RN  - 0 (Antibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 33X04XA5AT (Lactic Acid)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies/therapeutic use
MH  - Brain/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Escherichia coli Infections/immunology/metabolism/*therapy
MH  - Glucose/metabolism
MH  - Immunotherapy/methods
MH  - Intracranial Pressure
MH  - Lactic Acid/metabolism
MH  - Leukocyte Count
MH  - Meningitis, Bacterial/immunology/metabolism/microbiology/*therapy
MH  - Random Allocation
MH  - Swine
MH  - Tumor Necrosis Factor-alpha/cerebrospinal fluid/*immunology
EDAT- 1999/05/15 00:00
MHDA- 1999/05/15 00:01
CRDT- 1999/05/15 00:00
PHST- 1999/05/15 00:00 [pubmed]
PHST- 1999/05/15 00:01 [medline]
PHST- 1999/05/15 00:00 [entrez]
AID - 14118 [pii]
AID - 10.1159/000014118 [doi]
PST - ppublish
SO  - Biol Neonate. 1999;75(6):377-87. doi: 10.1159/000014118.