PMID- 10325701
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20190501
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Print)
IS  - 0003-9888 (Linking)
VI  - 80
IP  - 3
DP  - 1999 Mar
TI  - Insulin-like growth factor I, IGF binding protein 3, and IGFBP protease activity: 
      relation to anthropometric indices in solid tumours or leukaemia.
PG  - 226-30
AB  - OBJECTIVES: To measure the serum concentrations of insulin-like growth factor I 
      (IGF-I) and IGF binding protein 3 (IGFBP-3), and the level of IGFBP-3 protease 
      activity in 38 children presenting with malignancies, and to assess their 
      relation with auxological parameters and nutritional status. METHODS: Height, 
      weight, skinfold thickness, and mid-upper arm circumference (MUAC) were recorded 
      using standard techniques. IGF-I and IGFBP-3 were measured using specific 
      radioimmunoassays. Serum IGFBPs were also visualised on western ligand blot. 
      IGFBP-3 protease activity was assessed by the extent of fragmentation of 
      recombinant [125I]-IGFBP-3, compared with that induced by pregnancy serum. 
      Anthropometric and radioimmunoassay data were expressed as standard deviation 
      scores (SDS). RESULTS: The median (range) IGF-I SDS was significantly reduced in 
      all patients (-1.1 (-5.1 to 1.2)) and lower in children who were malnourished 
      (-2.5 (-3.9 to 0.1)). IGFBP-3 SDS was within the normal range for 31 of 38 
      patients but IGFBP-3 protease activity was raised in all patients. Neither 
      IGFBP-3 concentration nor protease activity was affected by nutritional status. 
      IGF-I correlated with MUAC (r = 0.41) and subscapular skinfold thickness SDS (r = 
      0.38), but not with weight, height, weight for height, or triceps skinfold 
      thickness. CONCLUSIONS: IGF-I is low in children with malignancies, and even 
      lower in those who are malnourished. IGFBP-3 concentrations were normal in most 
      patients but interpretation is complicated by the presence of raised IGFBP-3 
      protease activity, which could lead to overestimating concentrations of intact 
      peptide. IGF-I appears to relate to arm anthropometry as an index of nutritional 
      status but not height, weight, or weight for height, as would be expected in 
      normal children.
FAU - Brennan, B M
AU  - Brennan BM
AD  - Department of Paediatric Oncology, Manchester Children's Hospitals, UK.
FAU - Gill, M
AU  - Gill M
FAU - Pennells, L
AU  - Pennells L
FAU - Eden, O B
AU  - Eden OB
FAU - Thomas, A G
AU  - Thomas AG
FAU - Clayton, P E
AU  - Clayton PE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.99.- (insulin-like growth factor binding protein-3 protease)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Body Height
MH  - Body Weight
MH  - Child
MH  - Child, Preschool
MH  - Endopeptidases/*blood
MH  - Humans
MH  - Infant
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Leukemia/blood/complications
MH  - Neoplasms/*blood/complications
MH  - Nutrition Disorders/*blood/etiology
MH  - Skinfold Thickness
MH  - Statistics, Nonparametric
PMC - PMC1717861
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
PMCR- 2002/03/01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
PHST- 2002/03/01 00:00 [pmc-release]
AID - 10.1136/adc.80.3.226 [doi]
PST - ppublish
SO  - Arch Dis Child. 1999 Mar;80(3):226-30. doi: 10.1136/adc.80.3.226.