PMID- 10331580
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20190905
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 408
IP  - 1
DP  - 1999 May 24
TI  - Immunocytochemical localization of glutamate and gamma-aminobutyric acid in the 
      accessory olfactory bulb of the rat.
PG  - 61-72
AB  - The synaptic organization of the accessory olfactory bulb (AOB) was studied in 
      the rat with antibodies against the excitatory neurotransmitter glutamate (Glu) 
      and the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). To a large 
      extent, the immunoreactivity patterns produced by the two antibodies were 
      complementary. Glu-like immunoreactivity (-LI) was observed in the glomerular 
      neuropil, in the mitral cells, and in large neurons located in the periglomerular 
      region. Immunogold electron microscopy revealed particularly high levels of 
      Glu-LI in the axon terminals of vomeronasal neurons. GABA-LI was present in 
      granule and periglomerular cells and in their processes. The dendritic spines of 
      granule cells, which were presynaptic to mitral cells, were strongly labelled by 
      the antiserum against GABA. Labelling of serial semithin sections showed that the 
      GABA-positive and Glu-positive neurons of the periglomerular region are generally 
      distinct, and colocalization of Glu and GABA occurred only in a few cells. These 
      results are consistent with electrophysiological studies indicating that the 
      synaptic organization of the AOB is similar to that of the main olfactory bulb. 
      In both systems, Glu is the neurotransmitter used by primary afferents and output 
      neurons, whereas GABA is involved in the circuits underlying lateral and 
      feed-back inhibition.
FAU - Quaglino, E
AU  - Quaglino E
AD  - Dipartimento di Anatomia, Farmacologia e Medicina Legale, Universita di Torino, 
      Italia.
FAU - Giustetto, M
AU  - Giustetto M
FAU - Panzanelli, P
AU  - Panzanelli P
FAU - Cantino, D
AU  - Cantino D
FAU - Fasolo, A
AU  - Fasolo A
FAU - Sassoe-Pognetto, M
AU  - Sassoe-Pognetto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Female
MH  - Glutamic Acid/*analysis
MH  - Immunohistochemistry
MH  - Microscopy, Electron
MH  - Olfactory Bulb/*chemistry/cytology/ultrastructure
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/*chemistry/ultrastructure
MH  - gamma-Aminobutyric Acid/*analysis
EDAT- 1999/05/20 06:00
MHDA- 2000/06/20 09:00
CRDT- 1999/05/20 06:00
PHST- 1999/05/20 06:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/05/20 06:00 [entrez]
AID - 10.1002/(SICI)1096-9861(19990524)408:1<61::AID-CNE5>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1096-9861(19990524)408:1<61::aid-cne5>3.0.co;2-f [doi]
PST - ppublish
SO  - J Comp Neurol. 1999 May 24;408(1):61-72. doi: 
      10.1002/(sici)1096-9861(19990524)408:1<61::aid-cne5>3.0.co;2-f.