PMID- 10332000
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20190501
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Print)
IS  - 0003-9888 (Linking)
VI  - 80
IP  - 6
DP  - 1999 Jun
TI  - Anthropometry of patients with osteogenesis imperfecta.
PG  - 524-8
AB  - Standing height, sitting height, armspan, subischial leg length, head 
      circumference, and growth hormone-insulin-like growth factor I (IGF-I) axis were 
      determined in 86 patients with osteogenesis imperfecta. The aim of this study was 
      to determine standing height and body proportions and their variability among 
      osteogenesis imperfecta types and collagen defects. Mean standing height was 
      reduced in all groups of patients, to the greatest extent and variability in 
      osteogenesis imperfecta type III/IV and in those with qualitative collagen 
      defects. The mean standing height of patients with osteogenesis imperfecta was 
      lower than that of their unaffected first degree family members. Truncal height 
      of patients with osteogenesis imperfecta was reduced; head size was increased, 
      and this was more pronounced in patients with osteogenesis imperfecta type III/IV 
      and qualitative collagen defects than in patients with osteogenesis imperfecta 
      type I and quantitative collagen defects. Mean concentrations of IGF-I and IGF 
      binding protein 3 (IGFBP-3) were low, but most values were within age specific 
      reference values. The reduction of standing height appears to correlate with 
      osteogenesis imperfecta type and the type of collagen defect. A relatively short 
      trunk is typical and head circumference and body length are disproportionate.
FAU - Lund, A M
AU  - Lund AM
AD  - Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, DK-2100 
      Copenhagen, Denmark.
FAU - Muller, J
AU  - Muller J
FAU - Skovby, F
AU  - Skovby F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adolescent
MH  - *Anthropometry
MH  - Body Constitution
MH  - Body Height
MH  - Cephalometry
MH  - Child
MH  - Child, Preschool
MH  - Collagen/metabolism
MH  - Female
MH  - Growth Disorders/etiology
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Osteogenesis Imperfecta/blood/complications/*physiopathology
MH  - Sex Factors
PMC - PMC1717948
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
PMCR- 2002/06/01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
PHST- 2002/06/01 00:00 [pmc-release]
AID - 10.1136/adc.80.6.524 [doi]
PST - ppublish
SO  - Arch Dis Child. 1999 Jun;80(6):524-8. doi: 10.1136/adc.80.6.524.