PMID- 10332781
OWN - NLM
STAT- MEDLINE
DCOM- 19990702
LR  - 20220410
IS  - 0362-2436 (Print)
IS  - 0362-2436 (Linking)
VI  - 24
IP  - 10
DP  - 1999 May 15
TI  - Genetic analysis of ossification of the posterior longitudinal ligament.
PG  - 937-8; discussion 939
AB  - STUDY DESIGN: The human leukocyte antigen (HLA) haplotypes in families of 
      patients with known ossification of the posterior longitudinal ligament (OPLL) 
      were reviewed. OBJECTIVE: To clarify how genetic factors relate to the 
      development of OPLL. SUMMARY OF BACKGROUND DATA: The association between genetic 
      factors and the development of OPLL is still unknown. MATERIALS AND METHODS: The 
      association between HLA haplotypes and OPLL was studied in families of 24 
      patients with OPLL. RESULTS: The prevalence of OPLL was higher in the siblings 
      showing a higher share of identical HLA haplotypes: 10 (53%) of 19 with 
      concurrence of two strands, and 5 (24%) of 21 with concurrence of one strand. Of 
      21 subjects who had no HLA haplotype identical with that in OPLL patients, only 
      one showed evidence of OPLL. CONCLUSION: Genetic factors predispose toward the 
      development of OPLL.
FAU - Matsunaga, S
AU  - Matsunaga S
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, 
      Japan. shunji@med1.kufm.kagoshima-u.ac.jp
FAU - Yamaguchi, M
AU  - Yamaguchi M
FAU - Hayashi, K
AU  - Hayashi K
FAU - Sakou, T
AU  - Sakou T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/blood/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ossification of Posterior Longitudinal Ligament/blood/diagnostic 
      imaging/*genetics
MH  - Tomography, X-Ray Computed
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - 10.1097/00007632-199905150-00002 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 1999 May 15;24(10):937-8; discussion 939. doi: 
      10.1097/00007632-199905150-00002.