PMID- 10334426
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20221207
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 33
IP  - 6
DP  - 1999 May
TI  - Low incidence of transplant coronary artery disease in Chinese heart recipients.
PG  - 1573-7
AB  - OBJECTIVES: This study sought to assess the incidence of transplant coronary 
      artery disease (CAD) in Chinese heart recipients. BACKGROUND: The prevalence of 
      transplant CAD detected by angiography at 1, 2 and 4 years after heart 
      transplantation was 11%, 22% and 45%, respectively. The incidence of transplant 
      CAD in Chinese heart recipients has not been reported. METHODS: For those 
      recipients surviving for more than 1 year after transplantation, coronary 
      angiography was performed annually for surveillance of transplant CAD. The 
      recipient characteristics, donor characteristics, rejection episodes, medication 
      and human leukocyte antigen (HLA) mismatches were recorded. RESULTS: Fifty 
      patients were included in this study. Thirteen (26%) recipients had ischemic 
      heart disease. Two patients (4%) had active cytomegalovirus (CMV) infection after 
      transplantation. The mean number of rejection episodes in the 1st year after 
      transplantation was 1.15. Among 47 patients with complete data of donor and 
      recipient histocompatibility antigens, there were seven patients (14.9%) with two 
      or fewer HLA mismatches. Among 74 angiograms of 50 patients reviewed, only one 
      patient had discrete stenosis less than 50% in the middle portion of the left 
      anterior descending artery at 1 year after transplantation. The cumulative 
      incidence of transplant CAD was 2% at 1 year and 2% at 2 and 4 years after 
      transplantation. CONCLUSIONS: The incidence of transplant CAD was low in Chinese 
      heart transplant recipients. Low percentage of ischemic heart disease in 
      recipients, low occurrence of active CMV infection and rejection episodes after 
      transplantation, less racial disparity, and lower HLA mismatches may be the 
      important factors.
FAU - Hsu, R B
AU  - Hsu RB
AD  - Department of Surgery, National Taiwan University Hospital, Taipei.
FAU - Chu, S H
AU  - Chu SH
FAU - Wang, S S
AU  - Wang SS
FAU - Ko, W J
AU  - Ko WJ
FAU - Chou, N K
AU  - Chou NK
FAU - Lee, C M
AU  - Lee CM
FAU - Chen, M F
AU  - Chen MF
FAU - Lee, Y T
AU  - Lee YT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Asian People
MH  - Coronary Disease/epidemiology/*ethnology
MH  - *Cross-Cultural Comparison
MH  - Cross-Sectional Studies
MH  - Cytomegalovirus Infections/epidemiology/ethnology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology/ethnology
MH  - Heart Transplantation/*statistics & numerical data
MH  - Histocompatibility Testing/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology
MH  - Taiwan/epidemiology
MH  - United States/epidemiology
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - S0735-1097(99)00060-1 [pii]
AID - 10.1016/s0735-1097(99)00060-1 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1999 May;33(6):1573-7. doi: 10.1016/s0735-1097(99)00060-1.