PMID- 10336590
OWN - NLM
STAT- MEDLINE
DCOM- 19990714
LR  - 20190831
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 29
IP  - 6
DP  - 1999 Jun
TI  - High prevalence of sensitization to cat allergen among Japanese children with 
      asthma, living without cats.
PG  - 754-61
AB  - BACKGROUND: Cat allergy is common among children with asthma. Many cat-allergic 
      patients in Japan and elsewhere do not keep cats, but nonetheless become 
      sensitized through environmental exposure to cat allergen. OBJECTIVE: To assess 
      the frequency of cat allergy and cat-specific immunoglobulin E (IgE) and 
      immunoglobulin G (IgG) antibody responses in young Japanese patients with asthma 
      in relation to self-reported cat exposure and Fel d 1 levels in dust samples. 
      METHODS: Cat dander-specific IgE antibody was measured in sera from asthma 
      patients using the CAP system. IgE and IgG antibody to Fel d 1 was measured by 
      antigen binding radioimmunoassay and by chimeric enzyme immunoassay. Fel d 1 
      levels in dust samples from a subset of patients' homes were measured by 
      monoclonal antibody-based enzyme immunoassay. RESULTS: Cat-specific IgE (CAP 
      class>/=2) was found in sera from 70% of 44 patients who kept cats and 34% of 394 
      patients who had never kept cats. The prevalence of sensitization increased 
      progressively to age 6 years (40%: positive), and then increased gradually to age 
      16 years (approximately 60%: positive) in patients who had never kept cats. There 
      was an excellent correlation between cat CAP values and IgE levels to Fel d 1. 
      The absolute amount of IgE antibody to Fel d 1 ranged from 0.01 to 15.6% of total 
      IgE. Most patients who did not keep cats were exposed to Fel d 1 levels ranging 
      from 0.07-8 microg/g dust. CONCLUSIONS: Sensitization to cat allergen is common 
      among young asthmatic patients in Japan, even among patients who do not keep 
      cats. Use of CAP and the chimeric enzyme-linked immunosorbent assay allows 
      accurate diagnosis of cat allergy and quantification of specific IgE antibody 
      levels.
FAU - Ichikawa, K
AU  - Ichikawa K
AD  - Department of Pediatrics, Doai Memorial Hospital, Sumida-ku, Tokyo, Japan.
FAU - Iwasaki, E
AU  - Iwasaki E
FAU - Baba, M
AU  - Baba M
FAU - Chapman, M D
AU  - Chapman MD
LA  - eng
GR  - AI 32557/AI/NIAID NIH HHS/United States
GR  - AI 34607/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Antibodies)
RN  - 0 (Dust)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - G408EE88II (Fel d 1 protein, Felis domesticus)
SB  - IM
CIN - Clin Exp Allergy. 1999 Jun;29(6):725-8. PMID: 10336583
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Animals, Domestic
MH  - Antibodies/analysis/immunology
MH  - Asthma/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Dust/analysis
MH  - Female
MH  - Glycoproteins/analysis/*immunology
MH  - Humans
MH  - Hypersensitivity/*epidemiology/*immunology
MH  - Immunoglobulin E/analysis/immunology
MH  - Immunoglobulin G/analysis/immunology
MH  - Infant
MH  - Japan
MH  - Male
MH  - Prevalence
EDAT- 1999/05/21 00:00
MHDA- 1999/05/21 00:01
CRDT- 1999/05/21 00:00
PHST- 1999/05/21 00:00 [pubmed]
PHST- 1999/05/21 00:01 [medline]
PHST- 1999/05/21 00:00 [entrez]
AID - cea472 [pii]
AID - 10.1046/j.1365-2222.1999.00472.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 1999 Jun;29(6):754-61. doi: 10.1046/j.1365-2222.1999.00472.x.