PMID- 10336931
OWN - NLM
STAT- MEDLINE
DCOM- 20000906
LR  - 20190503
IS  - 1355-6037 (Print)
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 81
IP  - 6
DP  - 1999 Jun
TI  - Eosinophilic myocarditis associated with dense deposits of eosinophil cationic 
      protein (ECP) in endomyocardium with high serum ECP.
PG  - 669-71
AB  - A case of eosinophilic myocarditis following high serum levels of eosinophil 
      cationic protein (ECP) is described. A 27 year old woman was admitted with New 
      York Heart Association (NYHA) class III congestive heart failure. A 
      haematological study showed hypereosinophilia with degranulation and vacuoles; 
      the total eosinophil count was 7980/ml and the ECP serum concentration was 
      noticeably high at 150 ng/ml. Endomyocardial biopsy from the right ventricle 
      showed infiltration of eosinophils and dense deposits of ECP in the endocardium 
      as well as the myocardium. Steroid treatment returned the total eosinophil count 
      and serum ECP to normal, with satisfactory improvement in clinical features. 
      Eosinophilia may cause cardiac damage, and this report confirms that eosinophil 
      degranulation is toxic. Thus, serum ECP seems to be a reliable indicator for 
      diagnosis and for determining treatment parameters of eosinophilic myocarditis.
FAU - Arima, M
AU  - Arima M
AD  - Department of Internal Medicine, Division of Cardiology, Juntendo Urayasu 
      Hospital, Juntendo University School of Medicine, 2-1-1, Tomioka, Urayasu-shi, 
      Chiba 279-0002, Japan.
FAU - Kanoh, T
AU  - Kanoh T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adult
MH  - Blood Proteins/*analysis
MH  - Endocardium/*chemistry
MH  - Eosinophil Granule Proteins
MH  - Eosinophilia/*metabolism
MH  - Female
MH  - Humans
MH  - Myocarditis/*metabolism
MH  - *Ribonucleases
PMC - PMC1729068
EDAT- 1999/05/25 06:00
MHDA- 2000/09/09 11:01
PMCR- 2002/06/01
CRDT- 1999/05/25 06:00
PHST- 1999/05/25 06:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 1999/05/25 06:00 [entrez]
PHST- 2002/06/01 00:00 [pmc-release]
AID - 10.1136/hrt.81.6.669 [doi]
PST - ppublish
SO  - Heart. 1999 Jun;81(6):669-71. doi: 10.1136/hrt.81.6.669.