PMID- 10340293
OWN - NLM
STAT- MEDLINE
DCOM- 19990809
LR  - 20161124
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 52
IP  - 2
DP  - 1999 Feb
TI  - The selenium link: the missing link in our understanding of biochemical trigger 
      reactions?
PG  - 125-31
AB  - 'Inorganic' selenium (Se), e.g. selenite and selenate, is assumed to be 
      transformed into selenide and to be incorporated into selenoproteins, but this 
      has never been proved. There is evidence, however, that vitamin C reduces 
      selenite to elemental Se. Elemental sulphur (S) and Se bind easily to sulphides 
      and selenides, forming links containing two or more S or Se atoms. Such links 
      exist in natural minerals and have been found in proteins in living organisms. 
      There are many indications that selenocysteine in special proteins combines with 
      elemental Se to form Se links that transfer electrons from redoxable agents to 
      oxygen (O2). This implies a reduction to hydrogen peroxide (H2O2) or H2O, while 
      gaining energy and achieving trigger effects. H2O2 supplies anaerobic reactions 
      with energy eventually via adenosine 5'-triphosphate (ATP) or guanosine 
      5'-triphosphate (GTP). Without Se links, redoxable agents can be oxidized by 
      oxygen, which leads to the formation of oxygen products and inhibition of further 
      electron transference. Nitrous oxide (NO) is one product of oxidation that, 
      firmly binding to heme structures, may result in a system of protection. NO can 
      prevent O2 from binding to them and thereby stop destroying oxidations.
FAU - Nyberg-Swenson, B E
AU  - Nyberg-Swenson BE
AD  - swenson@fy-chalmers.se
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Catecholamines)
RN  - 0 (Proteins)
RN  - 0 (Selenoproteins)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - EC 1.17.1.4 (Xanthine Dehydrogenase)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
RN  - EC 3.6.5.1 (Transducin)
RN  - H6241UJ22B (Selenium)
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Animals
MH  - Catecholamines/metabolism
MH  - Electron Transport
MH  - Humans
MH  - Hydrogen Peroxide/metabolism
MH  - Iodide Peroxidase/metabolism
MH  - *Models, Biological
MH  - Nitrous Oxide/metabolism
MH  - Proteins/metabolism
MH  - Selenium/*metabolism
MH  - Selenoproteins
MH  - Transducin/metabolism
MH  - Xanthine Dehydrogenase/metabolism
MH  - Xanthine Oxidase/metabolism
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - S0306-9877(97)90633-2 [pii]
AID - 10.1054/mehy.1997.0633 [doi]
PST - ppublish
SO  - Med Hypotheses. 1999 Feb;52(2):125-31. doi: 10.1054/mehy.1997.0633.