PMID- 10340790
OWN - NLM
STAT- MEDLINE
DCOM- 19990709
LR  - 20191103
IS  - 0021-5155 (Print)
IS  - 0021-5155 (Linking)
VI  - 43
IP  - 2
DP  - 1999 Mar-Apr
TI  - Immunogenetics of uveitis in leprosy.
PG  - 97-102
AB  - PURPOSE: To identify any possible determinants in the development of uveitis in 
      leprosy patients. METHODS: Human leukocyte antigen (HLA) class I and II antigen, 
      and HLA class II genotypings were analyzed among Japanese leprosy patients. 
      Ninety-three unrelated Japanese leprosy patients (46 patients with a history of 
      uveitis and 47 patients without uveitis) and 114 healthy control subjects were 
      investigated. RESULTS: The occurrence of HLA-DR2 was significantly higher in 
      patients with uveitis (78.3%) than in those without uveitis (57.4%; odds ratio = 
      2.7, P<.05) and in the controls (33.3%; odds ratio = 7.2, P<.0000005, Pc<.00005). 
      The occurrence of HLA-DR4 was significantly lower in patients with uveitis 
      (15.2%) than in those without it (38.3%; odds ratio = 0.29, P<.05) and in the 
      controls (46.5%; odds ratio = 0.21, P<.0005, Pc<.05). Furthermore, the 
      frequencies of DR2-positive and DR4-negative genotypes were significantly higher 
      in patients with uveitis (69.6%) than in those without it (38.3%; odds ratio = 
      3.7, P<.005) and in the controls (21.9%; odds ratio = 8.1, P<.00000005). At the 
      genomic level, the occurrence of HLA-DQB1*0302 was significantly lower in the 
      patients with uveitis (8.7%) than in those without it (25.5%; odds ratio = 0.28, 
      P<.05). The distribution of HLA-DRB1 and DQA1 alleles was not significantly 
      different between the patients with and those without uveitis. However, the 
      frequencies of DRB1*1501-positive, as well as DRB1*0405- and DQB1*0302-negative 
      genotypes were significantly higher in the patients with uveitis (47.8%) than in 
      those without it (25.5%; odds ratio = 2.7, P<.05) and in the controls (8.8%; odds 
      ratio = 9.5, P<.00000005). CONCLUSIONS: Our results suggest that HLA Class II 
      genes confer susceptibility to or protection from leprous uveitis.
FAU - Joko, S
AU  - Joko S
AD  - Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
FAU - Numaga, J
AU  - Numaga J
FAU - Maeda, H
AU  - Maeda H
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Alleles
MH  - DNA/analysis
MH  - Female
MH  - Genotype
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Immunogenetics
MH  - Leprosy/*complications/genetics
MH  - Male
MH  - Odds Ratio
MH  - Uveitis/*complications/genetics
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - S0021515598000689 [pii]
AID - 10.1016/s0021-5155(98)00068-9 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 1999 Mar-Apr;43(2):97-102. doi: 10.1016/s0021-5155(98)00068-9.