PMID- 10341172
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20220128
IS  - 1080-6040 (Print)
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Linking)
VI  - 5
IP  - 3
DP  - 1999 May-Jun
TI  - Human herpesvirus 6: An emerging pathogen.
PG  - 353-66
AB  - Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two 
      variant groups (A and B) are recognized, is very common, approaching 100% in 
      seroprevalence. Primary infection with HHV-6B causes roseola infantum or exanthem 
      subitum, a common childhood disease that resolves spontaneously. After primary 
      infection, the virus replicates in the salivary glands and is shed in saliva, the 
      recognized route of transmission for variant B strains; it remains latent in 
      lymphocytes and monocytes and persists at low levels in cells and tissues. Not 
      usually associated with disease in the immunocompetent, HHV-6 infection is a 
      major cause of opportunistic viral infections in the immunosuppressed, typically 
      AIDS patients and transplant recipients, in whom HHV-6 infection/reactivation may 
      culminate in rejection of transplanted organs and death. Other opportunistic 
      viruses, human cytomegalovirus and HHV-7, also infect or reactivate in persons at 
      risk. Another disease whose pathogenesis may be correlated with HHV-6 is multiple 
      sclerosis. Data in favor of and against the correlation are discussed.
FAU - Campadelli-Fiume, G
AU  - Campadelli-Fiume G
AD  - University of Bologna, Italy. campadel@kaiser.alma.unibo.it
FAU - Mirandola, P
AU  - Mirandola P
FAU - Menotti, L
AU  - Menotti L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
SB  - IM
MH  - Adult
MH  - Central Nervous System Diseases/virology
MH  - Child
MH  - Exanthema Subitum/epidemiology/physiopathology
MH  - Genome, Viral
MH  - *Herpesviridae Infections/epidemiology/physiopathology/virology
MH  - *Herpesvirus 6, Human/genetics/pathogenicity
MH  - Herpesvirus 7, Human
MH  - Humans
MH  - Multiple Sclerosis/virology
MH  - Opportunistic Infections/virology
MH  - Sarcoma, Kaposi/virology
PMC - PMC2640789
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
PMCR- 1999/05/01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
PHST- 1999/05/01 00:00 [pmc-release]
AID - 10.3201/eid0503.990306 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 1999 May-Jun;5(3):353-66. doi: 10.3201/eid0503.990306.