PMID- 10341265
OWN - NLM
STAT- MEDLINE
DCOM- 19990616
LR  - 20231014
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 11
DP  - 1999 Jun 1
TI  - Relationships between the prefrontal cortex and the basal ganglia in the rat: 
      physiology of the cortico-nigral circuits.
PG  - 4674-81
AB  - The prelimbic/medial orbital areas (PL/MO) of the rat prefrontal cortex are 
      connected to substantia nigra pars reticulata (SNR) through three main circuits: 
      a direct nucleus accumbens (NAcc)-SNR pathway, an indirect NAcc-SNR pathway 
      involving the ventral pallidum (VP) and the subthalamic nucleus (STN), and a 
      disynaptic cortico-STN-SNR pathway. The present study was undertaken to 
      characterize the effect of PL/MO stimulation on SNR cells and to determine the 
      contribution of these different pathways. The major pattern of responses observed 
      in the SNR was an inhibition preceded by an early excitation and followed or not 
      by a late excitation. The inhibition resulted from the activation of the direct 
      NAcc-SNR pathway because it disappeared after acute blockade of the glutamatergic 
      cortico-striatal transmission by CNQX application into the NAcc. The late 
      excitation resulted from the activation of the indirect NAcc-VP-STN-SNR pathway 
      via a disinhibition of the STN because it disappeared after either CNQX 
      application into the NAcc or blockade of the GABAergic striato-pallidal 
      transmission by bicuculline application into the VP. The early excitation, which 
      was markedly decreased after blockade of the cortico-STN transmission by CNQX 
      application into the STN, resulted from the activation of the disynaptic 
      cortico-STN-SNR pathway. Finally, the blockade of the cortico-STN-VP circuit by 
      CNQX application into STN or VP modified the influence of the trans-striatal 
      circuits on SNR cells. This study suggests that, in the prefrontal cortex-basal 
      ganglia circuits, the trans-subthalamic pathways, by their excitatory effects, 
      participate in the shaping of the inhibitory influence of the direct 
      striato-nigral pathway on SNR neurons.
FAU - Maurice, N
AU  - Maurice N
AD  - Chaire de Neuropharmacologie, Institut National de la Sante et de la Recherche 
      Medicale U114, College de France, 75231 Paris Cedex 05, France.
FAU - Deniau, J M
AU  - Deniau JM
FAU - Glowinski, J
AU  - Glowinski J
FAU - Thierry, A M
AU  - Thierry AM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA Antagonists)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Basal Ganglia/*physiology
MH  - Bicuculline/pharmacology
MH  - Electric Stimulation
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Male
MH  - Neural Pathways/physiology
MH  - Nucleus Accumbens/drug effects/physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/drug effects/*physiology
PMC - PMC6782607
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
PMCR- 1999/12/01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
PHST- 1999/12/01 00:00 [pmc-release]
AID - 3088 [pii]
AID - 10.1523/JNEUROSCI.19-11-04674.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Jun 1;19(11):4674-81. doi: 10.1523/JNEUROSCI.19-11-04674.1999.