PMID- 10342408
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20220318
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 80
IP  - 3
DP  - 1999 Apr
TI  - Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a 
      behavioral and electrophysiological study.
PG  - 463-470
LID - 10.1016/S0304-3959(99)00042-1 [doi]
AB  - Nerve-growth factor (NGF), a member of the neurotrophin family, plays an 
      important role in nociceptor function. Prompted by a previous uinexpected finding 
      that NT-4/5, as well as NGF sensitizes single nociceptors to noxious heat, we 
      have explored the relative potency of all neurotrophins in eliciting thermal 
      hyperalgesia. NGF, brain-derived neurotrophic factor (BDNF), NT-4/5 and NT-3 were 
      injected locally into the hind paw of rats, and the behavioral response to 
      noxious heat was compared with that from the other paw that received an identical 
      injection of vehicle. Like NGF, agonists of tyrosine kinaseB (trkB) receptors 
      (NT-4/5 and BDN F) induced thermal hyperalgesia in the first 5 h after treatment 
      (NT-4/5 > BDNF) but the effect had worn off by 24 h. In contrast, the trkC 
      agonist NT-3 had no effect on the response to noxious heat. Electrophysiological 
      recordings from single C-fibres in the in vitro skin-saphenous nerve preparation 
      revealed sensitization to noxious heat stimuli after direct application of BDNF 
      to the receptive field, as previously noted for NT-4/5, and in parallel with the 
      behavioral findings. NT-3 was ineffective as in the behavioral studies. These 
      results suggest that trkB agonists BDNF and NT-4/5 as well as the trkA agonist 
      NGF can regulate nociceptive responses to noxious heat.
FAU - Shu, X-Q
AU  - Shu XQ
AD  - Department of Neurobiology and Behavior, State University of New York at Stony 
      Brook, Stony Brook, NY 11794, USA.
FAU - Llinas, A
AU  - Llinas A
FAU - Mendell, L M
AU  - Mendell LM
LA  - eng
GR  - P01 NS- 14899/NS/NINDS NIH HHS/United States
GR  - R01 NS 16696/NS/NINDS NIH HHS/United States
GR  - R01 NS- 32264/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 145172-44-7 (neurotrophin 5)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Electrophysiology
MH  - Female
MH  - Hot Temperature
MH  - Hyperalgesia/drug therapy/physiopathology
MH  - Male
MH  - Nerve Growth Factors/pharmacology
MH  - Neuroprotective Agents/*agonists
MH  - Neurotrophin 3
MH  - Nociceptors/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - Receptor Protein-Tyrosine Kinases/*chemistry
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkC
MH  - Receptors, Nerve Growth Factor/*agonists/*chemistry
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - 00006396-199904010-00002 [pii]
AID - 10.1016/S0304-3959(99)00042-1 [doi]
PST - ppublish
SO  - Pain. 1999 Apr;80(3):463-470. doi: 10.1016/S0304-3959(99)00042-1.