PMID- 10342589
OWN - NLM
STAT- MEDLINE
DCOM- 19990712
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 33
IP  - 5-6
DP  - 1999 May
TI  - Extramedullary relapse despite graft-versus-leukemia effect after bone marrow 
      transplantation in a girl with juvenile myelomonocytic leukemia.
PG  - 597-600
AB  - A 12 year-old girl with juvenile myelomonocytic leukemia (JMML) and monosomy 7 
      underwent allogeneic bone marrow transplantation (BMT) from her HLA-matched 
      brother. To monitor the engraftment and the course of the disease we used 
      fluorescence in situ hybridization (FISH) with probes specific for the 
      centromeres of chromosomes X, Y and 7. Complete hematological remission was 
      achieved and confirmed by the virtually exclusive presence of normal male cells 
      in the bone marrow (BM). Acute graft-versus host disease (GvHD) was treated with 
      prednisone and cyclosporine A (CSA) and female cells with monosomy 7 reoccurred 
      in the peripheral blood (PB) and BM. After discontinuation of the 
      immunosuppressive therapy, the leukemic cells with monosomy 7 disappeared again 
      from these compartments. One year after transplantation, isolated extramedullary 
      relapses occurred in lymph nodes and skin, followed by dissemination of blast 
      cells into the BM, whereas the PB cells remained of donor origin. The fact that 
      the leukemic cells fluctuated with the intensity of the immunosuppressive 
      treatment provides evidence of a graft versus leukemia (GvL) effect in this 
      unusually old girl with JMML with a unique extramedullary disease progression.
FAU - Kressler, E J
AU  - Kressler EJ
AD  - CCRI, St. Anna Kinderspital, Vienna, Austria.
FAU - Haas, O A
AU  - Haas OA
FAU - Konig, M
AU  - Konig M
FAU - Mann, G
AU  - Mann G
FAU - Mayer, H
AU  - Mayer H
FAU - Peters, C
AU  - Peters C
FAU - Gadner, H
AU  - Gadner H
FAU - Panzer-Grumayer, E R
AU  - Panzer-Grumayer ER
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Chromosomes, Human, Pair 7
MH  - Female
MH  - *Graft vs Tumor Effect
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myelomonocytic, Chronic/genetics/*pathology/*therapy
MH  - Male
MH  - Monosomy
MH  - Recurrence
MH  - Transplantation, Homologous
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - 10.3109/10428199909058466 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1999 May;33(5-6):597-600. doi: 10.3109/10428199909058466.