PMID- 10342608
OWN - NLM
STAT- MEDLINE
DCOM- 19990716
LR  - 20180607
IS  - 1055-6656 (Print)
IS  - 1055-6656 (Linking)
VI  - 36
IP  - 3
DP  - 1999 May
TI  - A multidisciplinary approach to the healing of cranial and residual maxillary 
      cleft defects by means of allogenous demineralized osseous implants and 
      polylactic acid casts in dogs.
PG  - 207-16
AB  - OBJECTIVE: The aim of this study was to evaluate the healing of artificially 
      induced bony defects in dogs by means of demineralized allogenous bone powder 
      (DBP) implants covered with polyhydroxy lactic acid (PLA) casts compared with DBP 
      implants without the casts. DESIGN: Prospective animal study. SETTING: Research 
      university. SAMPLE: Following a pilot study in which two dogs were used, four 
      mongrel dogs between the ages of 18 and 24 months and weighing approximately 20 
      kg were used as subjects. INTERVENTIONS: Each experimental animal had bilateral 
      maxillary alveolar clefts created. In a later procedure, each defect was repaired 
      with a DBP implant, half of which were covered with a PLA96 matrix. Each animal 
      also had a circular defect created in each parietal bone that was immediately 
      covered with DBP implants, half of which were similarly covered with a PLA96 
      disk. MAIN OUTCOME MEASURE: Repeated technetium-99m methylene-diphosphate (99mTC 
      MDP) uptake measurements were performed to evaluate bone metabolism during the 
      healing period, while at relevant intervals, radiographs were taken of the 
      healing alveolar cleft defects to register bone repair. After 1 year, the animals 
      were euthanized for macroscopic and histologic evaluation. RESULTS: 
      Histologically, the grafts covered with PLA96 were at a more advanced stage of 
      healing than those without, and the cranial defects similarly were more advanced 
      in the healing process than the alveolar defects. Uptake of 99mTC MDP into the 
      cranial implants was at its maximal level after 1 week and then gradually 
      decreased until, after 7 weeks, it was not significantly different from zero. 
      Cranial defects covered with a PLA95-enhanced implant showed a mean maximum count 
      rate of 275, while the plain DBP side showed a mean maximal count rate of 150. 
      Alveolar defects with the plain DBP implant showed a maximum count rate in the 
      first week; those with the PLA95 enhanced implant showed maximum uptake during 
      the second week. On both sides, there was a gradual decrease to the base value in 
      the seventh week. The mean maximum count on the PLA96-enhanced side was 285, 
      while on the plain DBP side, the corresponding value was 320. CONCLUSION: 
      Although an advantage of the combination was established for parietal cranial 
      defects, no advantage was seen for alveolar cleft defects in this experimental 
      setup.
FAU - Kuyl, M H
AU  - Kuyl MH
AD  - Department of Orthodontics, University of Gent, Belgium.
FAU - Thierens, H
AU  - Thierens H
FAU - Dermaut, L R
AU  - Dermaut LR
FAU - De Ridder, L
AU  - De Ridder L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cleft Palate Craniofac J
JT  - The Cleft palate-craniofacial journal : official publication of the American 
      Cleft Palate-Craniofacial Association
JID - 9102566
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 0 (Radiopharmaceuticals)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
SB  - IM
MH  - *Alveoloplasty
MH  - Animals
MH  - Bone Diseases/diagnostic imaging/pathology/*surgery
MH  - *Bone Plates
MH  - *Bone Transplantation
MH  - Cleft Palate/diagnostic imaging/pathology/*surgery
MH  - Decalcification Technique
MH  - Dogs
MH  - Follow-Up Studies
MH  - *Lactic Acid/chemistry
MH  - Maxilla/diagnostic imaging/pathology/*surgery
MH  - Parietal Bone/diagnostic imaging/pathology/*surgery
MH  - Pilot Projects
MH  - Polyesters
MH  - *Polymers/chemistry
MH  - Prospective Studies
MH  - Radiography
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - Technetium Tc 99m Medronate
MH  - Tissue Preservation
MH  - Transplantation, Homologous
MH  - Wound Healing
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - 10.1597/1545-1569_1999_036_0207_amatth_2.3.co_2 [doi]
PST - ppublish
SO  - Cleft Palate Craniofac J. 1999 May;36(3):207-16. doi: 
      10.1597/1545-1569_1999_036_0207_amatth_2.3.co_2.