PMID- 10342673
OWN - NLM
STAT- MEDLINE
DCOM- 19990809
LR  - 20080815
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 52
IP  - 1
DP  - 1999 Jan
TI  - How HIV-1 lentivirus causes immune deficiency disease.
PG  - 59-67
AB  - Human immunodeficiency virus (HIV-1) associated immune deficiency has the 
      characteristics of chronic graft versus host disease (GVHD) caused by human 
      leukocyte antigen (HLA) class 2 incompatibility. The envelope glycoprotein 
      fragment TKAKRRVVEREKR mimics HLA class 1 C molecules serologically, and also 
      mimics an immune regulatory T cell epitope, in the region of amino acids 67 to 
      71, within the HLA DR beta chain. This beta chain alloepitopic region (between 
      amino acids 67 to 80) furnishes peptides predicted to bind optimally to HLA class 
      1 B alleles. The hypothesis predicts that viral parameters, such as viral load, 
      and clinical parameters, such as rate of progress to acquired immune deficiency 
      syndrome (AIDS) and severity of the associated immune deficient state, are linked 
      to the HLA B and HLA DR beta chain haplotype in infected patients. Immune 
      suppression is caused by HLA class 1 B restricted CD8+ T cells which normally 
      regulate HLA class 2 DR restricted antigen specific responses. The hypothesis 
      further predicts the severity of immune deficiency to be linked to those HLA DR 
      beta chain allotypes which express the amino-acid glutamine (Q) in position 70.
FAU - Habeshaw, J A
AU  - Habeshaw JA
AD  - Department of Medical Microbiology, St Bartholomew's and the Royal London School 
      of Medicine & Dentistry, Whitechapel, UK.
FAU - Wilson, S E
AU  - Wilson SE
FAU - Hounsell, E F
AU  - Hounsell EF
FAU - Oxford, J S
AU  - Oxford JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Gene Products, env)
RN  - 0 (HLA Antigens)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Disease Models, Animal
MH  - Gene Products, env/genetics/immunology
MH  - Graft vs Host Disease/immunology
MH  - HIV Infections/*etiology/immunology
MH  - HIV-1/genetics/immunology/*pathogenicity
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Mice
MH  - *Models, Biological
MH  - Molecular Sequence Data
MH  - Peptide Fragments/genetics/immunology
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - S0306-9877(97)90632-0 [pii]
AID - 10.1054/mehy.1997.0632 [doi]
PST - ppublish
SO  - Med Hypotheses. 1999 Jan;52(1):59-67. doi: 10.1054/mehy.1997.0632.