PMID- 10342891
OWN - NLM
STAT- MEDLINE
DCOM- 19990604
LR  - 20190702
IS  - 0038-4348 (Print)
IS  - 0038-4348 (Linking)
VI  - 92
IP  - 5
DP  - 1999 May
TI  - Systemic sclerosis from autoimmunity to alloimmunity.
PG  - 472-6
AB  - BACKGROUND: The biologic significance of microchimerism from pregnancy in 
      systemic sclerosis and other autoimmune diseases is not fully characterized. 
      METHODS: We based this brief review on a systematic search of the MEDLINE 
      database for all relevant articles published between 1980 and July 1998, indexing 
      systemic sclerosis, microchimerism, and pregnancy as key words. We also searched 
      textbooks, meeting proceedings, and reference lists. RESULTS: Fetal 
      microchimerism and class II human leukocyte antigen (HLA) compatibility between 
      mother and fetus are common among women with systemic sclerosis. Alternative 
      sources of microchimerism include the engraftment of donor cells after a blood 
      transfusion, from a dizygotic twin, or possibly from the mother. CONCLUSIONS: 
      Systemic sclerosis could be a form of chronic graft-versus-host disease caused by 
      fetal or maternal cells, which have crossed the placenta and have remained 
      unrecognized by the host due to class II HLA compatibility.
FAU - Famularo, G
AU  - Famularo G
AD  - Department of Emergency Medicine, Ospedale San Camillo, Rome, Italy.
FAU - De Simone, C
AU  - De Simone C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Autoimmune Diseases/*immunology
MH  - Chimera
MH  - Female
MH  - Fetus/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Isoantigens/immunology
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
MH  - Scleroderma, Systemic/*immunology
RF  - 30
EDAT- 1999/05/26 00:00
MHDA- 1999/05/26 00:01
CRDT- 1999/05/26 00:00
PHST- 1999/05/26 00:00 [pubmed]
PHST- 1999/05/26 00:01 [medline]
PHST- 1999/05/26 00:00 [entrez]
AID - 10.1097/00007611-199905000-00004 [doi]
PST - ppublish
SO  - South Med J. 1999 May;92(5):472-6. doi: 10.1097/00007611-199905000-00004.