PMID- 10347547
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 111
IP  - 2
DP  - 1999 Jun
TI  - Frequent alterations of evolutionarily conserved regions of chromosome 1 in human 
      malignant melanoma.
PG  - 119-23
AB  - Recurring alterations of chromosome 1 represent the most frequent site of 
      structural chromosome abnormalities across all human solid tumors, including 
      human cutaneous malignant melanoma. In melanoma, breakpoints involving chromosome 
      1 appear to accumulate most frequently at the paracentromeric regions, and 
      secondly, to cluster within 1p36. Of interest, these three band regions (1p11-12, 
      1q21, and 1p36) were simultaneously recognized by a single YAC clone which was 
      isolated from sequences mapping to 1q21. This observation indicates the common 
      and highly conserved nature of sequences residing within these three bands. 
      Because of this finding, we have examined the possible association of these 
      recurring sites of rearrangements of chromosome 1 in malignant melanoma. To 
      elucidate genomic alterations in these regions, we have analyzed melanoma samples 
      simultaneously by fluorescence in situ hybridization (FISH) using both the YAC 
      clone encoding 1p11, 1q21, and 1p36 homologous sequences, and an alpha-satellite 
      probe for the chromosome 1 centromere. Twelve of 20 (60%) randomly selected 
      melanoma cell lines showed detectable rearrangements in one or more of the 
      chromosome 1 band regions. These results provide support for the notion that the 
      homology between these regions is associated with chromosomal instability, and 
      possibly, is of biologic relevance in malignant melanoma.
FAU - Zhang, J
AU  - Zhang J
AD  - Cancer Genetics Branch, National Institutes of Health, Bethesda, MD 20892-4470, 
      USA.
FAU - Glatfelter, A A
AU  - Glatfelter AA
FAU - Taetle, R
AU  - Taetle R
FAU - Trent, J M
AU  - Trent JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Disorders
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 1
MH  - Conserved Sequence
MH  - Contig Mapping
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma/*genetics
MH  - Mice
MH  - Sequence Tagged Sites
MH  - Skin Neoplasms/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - S0165460898001964 [pii]
AID - 10.1016/s0165-4608(98)00196-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jun;111(2):119-23. doi: 
      10.1016/s0165-4608(98)00196-4.