PMID- 10347552
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 111
IP  - 2
DP  - 1999 Jun
TI  - Multiple polysomies in breast carcinomas: preferential gain of chromosomes 1, 5, 
      6, 7, 12, 16, 17, 18, and 19.
PG  - 144-8
AB  - Chromosome G-banding analysis of metaphase cells from 16 primary breast 
      carcinomas revealed the presence of multiple polysomies in near-diploid as well 
      as in polyploid cells. Chromosome 17 was preferentially gained in 7 tumors, 
      followed in frequency by chromosomes 1, 12, and 19 (5 tumors each), and 
      chromosomes 5, 6, 7, 16, and 18 (4 tumors each). Eleven of the 16 carcinomas had, 
      apart from the clones exhibiting the numerical gains, other unrelated clones. 
      Nine of these 11 cases had clones with structural chromosome aberrations, 5 of 
      which had structural aberrations involving the short arm of chromosome 3. The 
      biologic significance, if any, of this seemingly nonrandom coexistence of 
      multiple polysomies with structural aberrations of 3p is at present not known. 
      The pattern of numerical chromosome aberrations observed in the present study is 
      comparable to previous results from fluorescence in situ hybridization (FISH) 
      studies, with the use of centromeric probes on interphase cells. However, unlike 
      FISH studies, which have been focused on chromosomes 1, 3, 7, 8, 11, 16, and 17, 
      the cytogenetic results reveal that other chromosomes also may be nonrandomly 
      gained as part of multiple polysomies in breast carcinomas. In addition, the 
      tumors with multiple polysomies were generally of high histologic grade and with 
      metastasis to axillary lymph nodes, suggesting that multiple wholechromosome 
      gains may be a pathway of genetic evolution or progression or both in some breast 
      carcinomas.
FAU - Adeyinka, A
AU  - Adeyinka A
AD  - Department of Clinical Genetics, University Hospital, Lund, Sweden.
FAU - Mertens, F
AU  - Mertens F
FAU - Idvall, I
AU  - Idvall I
FAU - Bondeson, L
AU  - Bondeson L
FAU - Pandis, N
AU  - Pandis N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*genetics/pathology
MH  - Carcinoma/*genetics/pathology/secondary
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Lymphatic Metastasis
MH  - Middle Aged
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - S0165460898002337 [pii]
AID - 10.1016/s0165-4608(98)00233-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jun;111(2):144-8. doi: 
      10.1016/s0165-4608(98)00233-7.