PMID- 10348334
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20220129
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 110
IP  - 1
DP  - 1999 Jan
TI  - Facilitation of rhythmic events in progressive myoclonus epilepsy: a transcranial 
      magnetic stimulation study.
PG  - 152-7
AB  - Twelve subjects with progressive myoclonus epilepsy (PME) were studied with 
      transcranial magnetic stimulation (TMS), using single and paired magnetic stimuli 
      at different interstimulus intervals (ISIs), and polygraphic recording. Motor 
      threshold (T) and silent period (SP) were normal. Paired TMS showed a loss of 
      inhibition at 100-150 ms ISI and a marked facilitation at 50 ms ISI of 
      conditioned motor evoked potential (MEP). Polygraphic analysis showed 20 Hz 
      oscillatory activity over the sensorimotor area coupled to contralateral 
      myoclonic jerks. These findings suggest a condition of increased supraspinal 
      excitability and support the evidence of a cortical rhythm in the range of 20 Hz. 
      No direct evidence exists that these findings are mediated by the same 
      intracortical pathway. Furthermore, the normal SP and T suggest that the abnormal 
      excitability is not a constant feature but is evident during rhythmic events.
FAU - Valzania, F
AU  - Valzania F
AD  - Divisione di Neurologia, Ospedale Bellaria, Universita di Bologna, Italy.
FAU - Strafella, A P
AU  - Strafella AP
FAU - Tropeani, A
AU  - Tropeani A
FAU - Rubboli, G
AU  - Rubboli G
FAU - Nassetti, S A
AU  - Nassetti SA
FAU - Tassinari, C A
AU  - Tassinari CA
LA  - eng
GR  - E.0444/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiopathology
MH  - Epilepsies, Myoclonic/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetoencephalography/*methods
MH  - Male
MH  - Neural Conduction/physiology
MH  - Reaction Time/physiology
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - S0013469498001151 [pii]
AID - 10.1016/s0013-4694(98)00115-1 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 1999 Jan;110(1):152-7. doi: 10.1016/s0013-4694(98)00115-1.