PMID- 10349862
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 72
IP  - 6
DP  - 1999 Jun
TI  - Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of 
      hydroxyl radicals and long-term depletion of serotonin in the striatum.
PG  - 2516-22
AB  - The formation of hydroxyl radicals following the systemic administration of 
      3,4-methylenedioxymethamphetamine (MDMA) was studied in the striatum of the rat 
      by quantifying the stable adducts of salicylic acid and D-phenylalanine, namely, 
      2,3-dihydroxybenzoic acid (2,3-DHBA) and p-tyrosine, respectively. The repeated 
      administration of MDMA produced a sustained increase in the extracellular 
      concentration of 2,3-DHBA and p-tyrosine, as well as dopamine. The MDMA-induced 
      increase in the extracellular concentration of both dopamine and 2,3-DHBA was 
      suppressed in rats treated with mazindol, a dopamine uptake inhibitor. Mazindol 
      also attenuated the long-term depletion of serotonin (5-HT) in the striatum 
      produced by MDMA without altering the acute hyperthermic response to MDMA. These 
      results are supportive of the view that MDMA produces a dopamine-dependent 
      increase in the formation of hydroxyl radicals in the striatum that may 
      contribute to the mechanism whereby MDMA produces a long-term depletion of brain 
      5-HT content.
FAU - Shankaran, M
AU  - Shankaran M
AD  - College of Pharmacy, University of Cincinnati, Ohio 45267-0004, USA.
FAU - Yamamoto, B K
AU  - Yamamoto BK
FAU - Gudelsky, G A
AU  - Gudelsky GA
LA  - eng
GR  - DA07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Hydroxybenzoates)
RN  - 333DO1RDJY (Serotonin)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 42HK56048U (Tyrosine)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - 70D5FBB392 (2,3-dihydroxybenzoic acid)
RN  - C56709M5NH (Mazindol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - O414PZ4LPZ (Salicylic Acid)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Hydroxybenzoates/metabolism
MH  - Hydroxyl Radical/*metabolism
MH  - Kinetics
MH  - Male
MH  - Mazindol/*pharmacology
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors/*pharmacology
MH  - Phenylalanine/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Salicylic Acid/pharmacokinetics
MH  - Serotonin/*metabolism
MH  - Tyrosine/metabolism
EDAT- 1999/06/01 00:00
MHDA- 1999/06/01 00:01
CRDT- 1999/06/01 00:00
PHST- 1999/06/01 00:00 [pubmed]
PHST- 1999/06/01 00:01 [medline]
PHST- 1999/06/01 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0722516.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Jun;72(6):2516-22. doi: 10.1046/j.1471-4159.1999.0722516.x.