PMID- 10350329
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 34
IP  - 1-2
DP  - 1999 Jun
TI  - Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with 
      t(9;14)(p13;q32).
PG  - 25-33
AB  - B-cell non-Hodgkin's lymphoma (NHL) consists of heterogeneous subtypes based on 
      histologic, immunophenotypic, and clinical findings. Recent advances in molecular 
      biology have provided us new insights into the pathogenesis of this neoplasm at 
      the genetic level, such as the deregulation of the protooncogenes adjoining the 
      immunoglobulin gene (Ig) loci, which is a specific event in mature B-cell tumors. 
      Moreover, involvement of certain protooncogenes corresponds to certain subtypes 
      of NHL. Recently, we found that t(9;14)(p13;q32) chromosomal translocation 
      associated with lymphoplasmacytic lymphoma (LPL) juxtaposes PAX-5 gene encoding 
      for an essential transcription factor (BSAP: B-cell specific activator protein) 
      for B-cell proliferation and differentiation to the Ig heavy chain gene (IgH) 
      locus. This results in deregulated expression of the PAX-5 mRNA. We also 
      developed a diagnostic FISH (fluorescence in situ hybridization) procedure which 
      is able to detect 80% of the widely scattering 9p13 breakpoints involved in this 
      translocation. Thus, an understanding of the PAX-5 gene's physiological role in 
      B-cell development and the pathological role in tumorigenesis may lead to the 
      optimal clinical treatment strategy for LPL and LPL-derived diffuse large cell 
      lymphoma (DLCL).
FAU - Iida, S
AU  - Iida S
AD  - Department of Pathology, College of Physicians and Surgeons, Columbia University, 
      New York, NY, USA. iida@med.nagoya-cu.ac.jp
FAU - Rao, P H
AU  - Rao PH
FAU - Ueda, R
AU  - Ueda R
FAU - Chaganti, R S
AU  - Chaganti RS
FAU - Dalla-Favera, R
AU  - Dalla-Favera R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (PAX5 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 9
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Rearrangement
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lymphoma, B-Cell/*genetics
MH  - Nuclear Proteins/*genetics
MH  - PAX5 Transcription Factor
MH  - *Transcription Factors
MH  - *Translocation, Genetic
RF  - 51
EDAT- 1999/06/01 00:00
MHDA- 1999/06/01 00:01
CRDT- 1999/06/01 00:00
PHST- 1999/06/01 00:00 [pubmed]
PHST- 1999/06/01 00:01 [medline]
PHST- 1999/06/01 00:00 [entrez]
AID - 10.3109/10428199909083377 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1999 Jun;34(1-2):25-33. doi: 10.3109/10428199909083377.