PMID- 10350547
OWN - NLM
STAT- MEDLINE
DCOM- 19990802
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 829
IP  - 1-2
DP  - 1999 May 22
TI  - Trophic effects of selegiline on cultured dopaminergic neurons.
PG  - 190-2
AB  - Trophic effects of the neuroprotective agent selegiline on cultured dopaminergic 
      neurons were investigated and compared with the effects produced by brain derived 
      neurotrophic factor (BDNF). Both treatments increased the total length of 
      TH-positive neurites, but selegiline increased the average length of neuritic 
      branches, whereas BDNF increased the formation of new branches. This trophic 
      effect of selegiline may contribute to its action in neurodegenerative disease 
      treatment.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Kontkanen, O
AU  - Kontkanen O
AD  - A.I. Virtanen Institute and Department of Psychiatry, University of Kuopio, P.O. 
      Box 1627, 70211, Kuopio, Finland.
FAU - Castren, E
AU  - Castren E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 2K1V7GP655 (Selegiline)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dopamine/*physiology
MH  - Nerve Growth Factors/*pharmacology
MH  - Neurons/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Selegiline/*pharmacology
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - S0006-8993(99)01363-3 [pii]
AID - 10.1016/s0006-8993(99)01363-3 [doi]
PST - ppublish
SO  - Brain Res. 1999 May 22;829(1-2):190-2. doi: 10.1016/s0006-8993(99)01363-3.