PMID- 10351921
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20101118
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 159
IP  - 6
DP  - 1999 Jun
TI  - Suggestive evidence for genetic linkage between IgE phenotypes and chromosome 14q 
      markers.
PG  - 1796-802
AB  - Chromosome 14q was screened for loci modulating immunoglobulin E (IgE) phenotypes 
      in 15 extended and 45 nuclear asthmatic families using a panel of 14 
      microsatellite markers. We examined the reported linkage between the TCR A/D 
      locus on 14q11.2 and specific (cognate) allergic responses and observed 
      supportive evidence for linkage between a general skin prick test reactivity 
      trait (but not with total serum IgE) and TCRA microsatellite (in the total sample 
      of informative sib-pairs p = 0.039, in selected sample of one or zero affected 
      parent p = 0.017). We also show suggestive evidence for a novel linkage between 
      markers D14S75 and D14S63 on 14q13-23 and log total serum IgE (p = 0.034 and p = 
      0.0029). The evidence for linkage with marker D14S63 on 14q23 is strengthened by 
      the finding of association of allele 165 to log IgE (p = 0.0029). We conclude 
      that chromosome 14q may contain a locus close to TCR A/D at 14q11.2 linked to 
      skin prick reactivity and a locus at 14q13- 23 linked to total serum IgE.
FAU - Mansur, A H
AU  - Mansur AH
AD  - Molecular Medicine Unit and ICRF, Ashley Wing, St. James's University Hospital, 
      Leeds, UK.
FAU - Bishop, D T
AU  - Bishop DT
FAU - Markham, A F
AU  - Markham AF
FAU - Morton, N E
AU  - Morton NE
FAU - Holgate, S T
AU  - Holgate ST
FAU - Morrison, J F
AU  - Morrison JF
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Allergens)
RN  - 0 (Genetic Markers)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Allergens/immunology
MH  - Asthma/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Female
MH  - Genetic Linkage/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - Immunoglobulin E/*genetics
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Skin Tests
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - 10.1164/ajrccm.159.6.9804036 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1999 Jun;159(6):1796-802. doi: 
      10.1164/ajrccm.159.6.9804036.