PMID- 10353349
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 266
IP  - 2
DP  - 1999 May 7
TI  - Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome 
      P450 2D6 genetic polymorphism.
PG  - 149-51
AB  - Brain tissue of 50 patients with morphological confirmed Parkinson's disease 
      (PD), blood samples from 149 patients with clinical parkinsonism and from 96 
      healthy control subjects were collected. Apolipoprotein-E (apo E) and cytochrome 
      P450 2D6 (CYP2D6) genotyping were performed by PCR followed by restriction 
      fragment analysis. A significantly higher allele frequency of CYP2D6*4 was found 
      in patients with PD (35%) but not with parkinsonism (14.1%) compared to control 
      subjects (19.8%). The combined alleles frequency of CYP2D6*3 + apoE4 was 
      significantly higher not only in the PD group (33.3%) but also in patients with 
      parkinsonism (22.3%) compared to control subjects (1.6%). These results suggest 
      that there is a substantial overlap not only in the clinical manifestation but 
      also in the genetic risk factors between Parkinson's and Alzheimer's diseases.
FAU - Bon, M A
AU  - Bon MA
AD  - Department of Clinical Chemistry, Medical Spectrum Twente, Hospital Group, 
      Enschede, The Netherlands.
FAU - Jansen Steur, E N
AU  - Jansen Steur EN
FAU - de Vos, R A
AU  - de Vos RA
FAU - Vermes, I
AU  - Vermes I
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Apolipoproteins E)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
SB  - IM
MH  - Apolipoproteins E/*genetics
MH  - Case-Control Studies
MH  - Cytochrome P-450 CYP2D6/*genetics
MH  - Cytochrome P-450 Enzyme System/*genetics
MH  - Disease Progression
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Parkinson Disease/*genetics/pathology
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - S0304-3940(99)00278-5 [pii]
AID - 10.1016/s0304-3940(99)00278-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 May 7;266(2):149-51. doi: 10.1016/s0304-3940(99)00278-5.