PMID- 10353860
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20081121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 180
IP  - 1
DP  - 1999 Jul
TI  - Primary infection of human herpesvirus 6 in children with vertical infection of 
      human immunodeficiency virus type 1.
PG  - 50-5
AB  - The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human 
      immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 
      HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA in the first month of 
      life, suggesting possible intrauterine infection. The cumulative infection rates 
      of HHV-6 at 6 and 12 months of age were significantly lower in HIV-infected 
      children (11% and 33%, respectively) than in uninfected children (28% and 78%, 
      respectively; P<.001). There was an association between high CD4+ cell numbers 
      (>15%) before HHV-6 infection and high HHV-6 infection rate. Twenty-two infants 
      with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 
      were studied for an association of HHV-6 infection with progression of HIV 
      disease. Ten of the infants had HHV-6, and 12 did not. In 5 of the infants 
      without HHV-6 (42%), HIV disease had not progressed by 1 year of age; however, 
      HIV disease had progressed in all 10 children with HHV-6 infection. These results 
      suggest an association of HHV-6 infection and progression of HIV disease in the 
      study children with vertical HIV-1 infection (P<.05).
FAU - Kositanont, U
AU  - Kositanont U
AD  - Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand. gruks@mahidol.ac.th
FAU - Wasi, C
AU  - Wasi C
FAU - Wanprapar, N
AU  - Wanprapar N
FAU - Bowonkiratikachorn, P
AU  - Bowonkiratikachorn P
FAU - Chokephaibulkit, K
AU  - Chokephaibulkit K
FAU - Chearskul, S
AU  - Chearskul S
FAU - Chimabutra, K
AU  - Chimabutra K
FAU - Sutthent, R
AU  - Sutthent R
FAU - Foongladda, S
AU  - Foongladda S
FAU - Inagi, R
AU  - Inagi R
FAU - Kurata, T
AU  - Kurata T
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
SB  - IM
MH  - CD4 Lymphocyte Count
MH  - DNA, Viral/blood
MH  - HIV Seropositivity/complications/*epidemiology/transmission
MH  - *HIV-1
MH  - Herpesviridae Infections/complications/*epidemiology
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Prevalence
MH  - Thailand/epidemiology
EDAT- 1999/06/03 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/06/03 10:00
PHST- 1999/06/03 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/06/03 10:00 [entrez]
AID - JID981086 [pii]
AID - 10.1086/314826 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Jul;180(1):50-5. doi: 10.1086/314826.