PMID- 10354139
OWN - NLM
STAT- MEDLINE
DCOM- 19990721
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 105
IP  - 3
DP  - 1999 Jun
TI  - Chromosome aberrations are restricted to the CD56+, CD3- tumour cell population 
      in natural killer cell lymphomas: a combined immunophenotyping and FISH study.
PG  - 737-42
AB  - Natural killer (NK) cell lymphomas are a newly recognized entity of non-Hodgkin's 
      lymphoma with a highly aggressive clinical course and strong association with 
      Epstein-Barr virus (EBV) infection. Although no recurrent chromosome aberrations 
      have been identified in NK-cell lymphoma, deletions of 6q and trisomy 7 have been 
      described repeatedly in this type of lymphoma. In this study we attempted to 
      determine the immunophenotypes of tumour cells with certain chromosome 
      aberrations, i.e. deletions of 6q and trisomy 7, in three cases of NK cell 
      lymphomas by means of combined immunophenotyping and fluorescence in situ 
      hybridization (FISH). In all three cases clonal chromosome aberrations were 
      detected only in CD56+ cells but not in CD3+ or CD5+ cells. However, not all 
      CD56+ cells were shown to contain these chromosome aberrations. Double 
      immunophenotyping combined with FISH confirmed that the chromosome aberrations 
      occurred only in CD56+CD3- cells. This study indicates that chromosome 
      aberrations in NK-cell lymphomas are restricted to the CD56+, CD3- and CD5- cell 
      population and that NK-cell lymphomas are indeed derived from mature true NK 
      cells and not from T lymphocytes.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Department of Human Genetics, University of Kiel, Kiel, Germany.
FAU - Wong, K F
AU  - Wong KF
FAU - Siebert, R
AU  - Siebert R
FAU - Matthiesen, P
AU  - Matthiesen P
FAU - Harder, S
AU  - Harder S
FAU - Eimermacher, H
AU  - Eimermacher H
FAU - Feller, A C
AU  - Feller AC
FAU - Schlegelberger, B
AU  - Schlegelberger B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Killer Cells, Natural/*pathology
MH  - Lymphoma, T-Cell/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - bjh1410 [pii]
AID - 10.1046/j.1365-2141.1999.01410.x [doi]
PST - ppublish
SO  - Br J Haematol. 1999 Jun;105(3):737-42. doi: 10.1046/j.1365-2141.1999.01410.x.