PMID- 10354708
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20220227
IS  - 0079-6107 (Print)
IS  - 0079-6107 (Linking)
VI  - 71
IP  - 3-4
DP  - 1999
TI  - The role of SHIP in growth factor induced signalling.
PG  - 423-34
AB  - The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing 
      inositol phosphatase, SHIP, is rapidly gaining prominence as a potential 
      regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has 
      been shown both in vitro and in vivo to hydrolyze the 5' phosphate from 
      phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more 
      widely expressed counterpart, SHIP2, could play a central role in determining 
      PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo 
      function of SHIP further we recently generated a SHIP knock out mouse and in this 
      review we discuss experiments carried out with bone marrow derived mast cells 
      (BMMCs) from these animals.
FAU - Huber, M
AU  - Huber M
AD  - Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada.
FAU - Helgason, C D
AU  - Helgason CD
FAU - Damen, J E
AU  - Damen JE
FAU - Scheid, M
AU  - Scheid M
FAU - Duronio, V
AU  - Duronio V
FAU - Liu, L
AU  - Liu L
FAU - Ware, M D
AU  - Ware MD
FAU - Humphries, R K
AU  - Humphries RK
FAU - Krystal, G
AU  - Krystal G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Prog Biophys Mol Biol
JT  - Progress in biophysics and molecular biology
JID - 0401233
RN  - 0 (Growth Substances)
RN  - 0 (Phosphatidylinositols)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.86 (INPPL1 protein, human)
RN  - EC 3.1.3.86 (Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - Growth Substances/*physiology
MH  - Humans
MH  - Mast Cells/cytology/physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
MH  - Phosphatidylinositols/metabolism
MH  - Phosphoric Monoester Hydrolases/*metabolism
MH  - *Signal Transduction
MH  - src Homology Domains
RF  - 72
EDAT- 1999/06/04 00:00
MHDA- 1999/06/04 00:01
CRDT- 1999/06/04 00:00
PHST- 1999/06/04 00:00 [pubmed]
PHST- 1999/06/04 00:01 [medline]
PHST- 1999/06/04 00:00 [entrez]
AID - S0079-6107(98)00049-2 [pii]
AID - 10.1016/s0079-6107(98)00049-2 [doi]
PST - ppublish
SO  - Prog Biophys Mol Biol. 1999;71(3-4):423-34. doi: 10.1016/s0079-6107(98)00049-2.