PMID- 10354818
OWN - NLM
STAT- MEDLINE
DCOM- 19990721
LR  - 20151119
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 27
IP  - 1
DP  - 1999
TI  - The evaluation of antianaphylactic effect of Oryza sativa L. in rats.
PG  - 63-71
AB  - This study was carried out to examine the effect of methanol extract of Oryza 
      sativa L. (Dong-Jin in Korean, abbreviate as Os-DJ hereafter) on anaphylaxis. 
      Os-DJ (10(-5) to 1 g/kg) dose-dependently inhibited systemic anaphylaxis induced 
      by compound 48/80 in rats. When Os-DJ was pretreated at concentration ranging 
      from 10(-5) to 1 g/kg, the serum histamine levels were reduced in a 
      dose-dependent manner. Os-DJ (1 g/kg) also significantly inhibited local 
      anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, Os-DJ 
      dose-dependently inhibited the histamine release from rat peritoneal mast cells 
      (RPMC) activated by compound 48/80 or anti-DNP IgE. These results indicate that 
      Os-DJ possess antianaphylactic activity by inhibition of histamine release from 
      mast cells in vivo and in vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, Korea.
FAU - Yi, D K
AU  - Yi DK
FAU - Shin, H Y
AU  - Shin HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/drug therapy/*prevention & control
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Histamine Release/drug effects
MH  - *Oryza
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1999/06/04 00:00
MHDA- 1999/06/04 00:01
CRDT- 1999/06/04 00:00
PHST- 1999/06/04 00:00 [pubmed]
PHST- 1999/06/04 00:01 [medline]
PHST- 1999/06/04 00:00 [entrez]
AID - S0192415X99000094 [pii]
AID - 10.1142/S0192415X99000094 [doi]
PST - ppublish
SO  - Am J Chin Med. 1999;27(1):63-71. doi: 10.1142/S0192415X99000094.