PMID- 10357068 OWN - NLM STAT- MEDLINE DCOM- 19990723 LR - 20190719 IS - 0361-9230 (Print) IS - 0361-9230 (Linking) VI - 48 IP - 4 DP - 1999 Mar 1 TI - Neurotrophin-like immunoreactivity in the human hippocampal formation. PG - 375-82 AB - The immunohistochemical occurrence and localisation of the neurotrophins nerve growth factor, brain-derived neurotrophic factor (BDNF), neurotrophin-4, and neurotrophin-3 is described in the human post-mortem hippocampal formation from subjects aged 23 weeks of gestation to 68 years. Labeled neuronal cell bodies and processes were detectable for each neurotrophin at all examined ages with age-related changes in their distribution pattern. As a general rule, a higher number of immunoreactive perikarya was found in subjects at pre- and perinatal ages than in adults. At variance with the other neurotrophins, the BDNF antiserum labelled also extensive nerve fibre systems, whose occurrence and distribution widened with age. The results obtained provide a morphological ground in support to the concept that the neurotrophins play a functional role in the human hippocampal circuitry throughout life. FAU - Quartu, M AU - Quartu M AD - Dipartimento di Citomorfologia, Universita di Cagliari, Cittadella Universitaria di Monserrato, Italy. dfiacco@unica.it FAU - Lai, M L AU - Lai ML FAU - Del Fiacco, M AU - Del Fiacco M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Brain Res Bull JT - Brain research bulletin JID - 7605818 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Neurotrophin 3) RN - P658DCA9XD (neurotrophin 4) SB - IM MH - Aged MH - Aging/metabolism MH - Brain-Derived Neurotrophic Factor/metabolism MH - Female MH - Fetus/metabolism MH - Hippocampus/embryology/*metabolism MH - Humans MH - Immunohistochemistry MH - Infant MH - Infant, Newborn MH - Male MH - Middle Aged MH - Nerve Growth Factors/*metabolism MH - Neurotrophin 3 MH - Tissue Distribution/physiology EDAT- 1999/06/05 00:00 MHDA- 1999/06/05 00:01 CRDT- 1999/06/05 00:00 PHST- 1999/06/05 00:00 [pubmed] PHST- 1999/06/05 00:01 [medline] PHST- 1999/06/05 00:00 [entrez] AID - S0361-9230(99)00009-X [pii] AID - 10.1016/s0361-9230(99)00009-x [doi] PST - ppublish SO - Brain Res Bull. 1999 Mar 1;48(4):375-82. doi: 10.1016/s0361-9230(99)00009-x.