PMID- 10359062
OWN - NLM
STAT- MEDLINE
DCOM- 19990623
LR  - 20190909
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 62
IP  - 5
DP  - 1999 May
TI  - Kinetics of indium-111-labelled platelets in HIV-infected patients with and 
      without associated thrombocytopaenia.
PG  - 332-5
AB  - Seven to 12% of HIV-infected patients have thrombocytopaenia. The pathophysiology 
      of the thrombocytopaenia is not clear. It has been variously suggested that it 
      may be caused by an increased peripheral platelet destruction, a defect in 
      platelet production, or by a combination of these. The aim of the study was to 
      elucidate the pathogenesis of HIV-associated thrombocytopaenia. We determined the 
      mean platelet life span (MPLS) and calculated the turnover of autologous 
      indium-111-labelled platelets in 17 HIV-positive patients, seven with 
      thrombocytopaenia. The sites of sequestration of labelled platelets were 
      quantified. The thrombocytopaenic patients had a very short MPLS (3.0+/-3.8 h) 
      and a marked increase in platelet production (18.2+/-12.6x10(9)/l/h). The 
      majority of these patients (5 of 7) had excessive sequestration of platelets in 
      the spleen. Five of the patients with a normal blood platelet count had a 
      shortened MPLS (109+/-23 h) and increased platelet turnover 
      (3.8+/-1.2x10(9)/l/h), i.e. the increased peripheral platelet destruction was 
      compensated for by increased platelet production. The other five patients with a 
      normal platelet count had normal MPLS (195+/-11 h) and slightly increased 
      platelet production (2.5+/-0.6x10(9)/l/h). We conclude that patients with 
      HIV-associated thrombocytopaenia have increased peripheral platelet destruction. 
      Platelet production is elevated but is insufficient to maintain a normal 
      peripheral platelet count. In these patients platelets are predominantly 
      sequestrated in the spleen. Patients with HIV infection and a normal blood 
      platelet count may also have increased platelet production. This may be an early 
      subclinical phase in the development of full-blown HIV-associated 
      thrombocytopaenia.
FAU - Van Wyk, V
AU  - Van Wyk V
AD  - Department of Haematology and Cell Biology, University of the Orange Free State, 
      Bloemfontein, South Africa.
FAU - Kotze, H F
AU  - Kotze HF
FAU - Heyns, A P
AU  - Heyns AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (Indium Radioisotopes)
SB  - IM
MH  - Adult
MH  - Blood Platelets/pathology/*physiology
MH  - Female
MH  - HIV Infections/blood/complications/*physiopathology
MH  - *HIV-1
MH  - Half-Life
MH  - Humans
MH  - Indium Radioisotopes
MH  - Kinetics
MH  - Male
MH  - Thrombocytopenia/blood/etiology/pathology/*physiopathology
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1111/j.1600-0609.1999.tb01911.x [doi]
PST - ppublish
SO  - Eur J Haematol. 1999 May;62(5):332-5. doi: 10.1111/j.1600-0609.1999.tb01911.x.