PMID- 10360246
OWN - NLM
STAT- MEDLINE
DCOM- 19990728
LR  - 20190831
IS  - 0301-4800 (Print)
IS  - 0301-4800 (Linking)
VI  - 45
IP  - 1
DP  - 1999 Jan
TI  - An evaluation of the bioavailability of selenium in high-selenium yeast.
PG  - 119-28
AB  - The bioavailability of selenium (Se) in high-Se yeast (SeY) was evaluated by 
      measuring tissue Se accumulation and glutathione peroxidase (GSHPx) activity. For 
      4 weeks, 4-week-old male Wistar rats were fed a Torula yeast-based Se-deficient 
      diet (basal diet) or a diet supplemented with a graded level (0.04, 0.08, 0.16, 
      and 0.32 microgram/g) of Se as either sodium selenite or SeY, which was obtained 
      from two different sources. Se supplementation did not influence growth, 
      hematological values, or serum biochemical tests. Se contents and GSHPx 
      activities in the liver, serum, and erythrocytes increased gradually with 
      increases of the supplemented Se. At lower Se levels (0.04 and 0.08 microgram/g), 
      selenite produced higher Se deposition and higher GSHPx activities than SeY did, 
      but at a higher Se level (0.32 microgram/g), SeY showed higher measures. Strong 
      correlations were detected between the supplementary Se levels and the tissue Se 
      contents or GSHPX activities when the regression was fitted to this equation: 
      R-Rb = m log X + k, where R represented tissue Se content or GSHPx activity in 
      rats fed the diet supplemented with Se at X level, Rb corresponding mean value in 
      rats fed the basal diet, m slope, and k constant. The bioavailability of Se in 
      SeY, as assessed by slope ratio analysis using selenite as a reference Se, was 
      135% to 165% in the tissue Se content and 105% to 197% in the GSHPx activities. 
      These results indicate that Se in SeY is more bioavailable than selenite Se, and 
      therefore it is the preferred form for supplementation.
FAU - Yoshida, M
AU  - Yoshida M
AD  - Department of Biotechnology, Faculty of Engineering, Kansai University, Osaka, 
      Japan.
FAU - Fukunaga, K
AU  - Fukunaga K
FAU - Tsuchita, H
AU  - Tsuchita H
FAU - Yasumoto, K
AU  - Yasumoto K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
RN  - HIW548RQ3W (Sodium Selenite)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - *Cryptococcus/*chemistry
MH  - *Diet
MH  - Dietary Supplements
MH  - Erythrocytes/enzymology
MH  - Glutathione Peroxidase/blood/metabolism
MH  - Liver/enzymology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Saccharomyces cerevisiae/*chemistry
MH  - Selenium/administration & dosage/*pharmacokinetics
MH  - Sodium Selenite/administration & dosage/pharmacokinetics
EDAT- 1999/06/09 00:00
MHDA- 1999/06/09 00:01
CRDT- 1999/06/09 00:00
PHST- 1999/06/09 00:00 [pubmed]
PHST- 1999/06/09 00:01 [medline]
PHST- 1999/06/09 00:00 [entrez]
AID - 10.3177/jnsv.45.119 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 1999 Jan;45(1):119-28. doi: 10.3177/jnsv.45.119.