PMID- 10360808
OWN - NLM
STAT- MEDLINE
DCOM- 19990616
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 21
IP  - 2
DP  - 1999 Jun 1
TI  - Infection by different HIV-1 subtypes (B and C) results in a similar immune 
      activation profile despite distinct immune backgrounds.
PG  - 157-63
AB  - We compared the immune activation profile of 46 HIV-negative and 75 HIV-positive 
      Israelis infected with HIV-1 subtype B, with 85 HIV-negative and 102 HIV-positive 
      Ethiopian immigrants to Israel, who were infected with HIV subtype C. The 
      HIV-negative Ethiopians had exceedingly high blood levels of eosinophils, 
      immunoglobulin E (IgE), and p75s tumor-necrosis factor receptors (p75sTNFR); 
      secretion of interleukin-4 (IL-4) and IL-10 by peripheral blood mononuclear cells 
      (PBMC); proportion of human leukocyte antigen (HLA)-DR+ cells within CD3+, CD4+, 
      and CD8+ T-cell subsets; and proportion of CD45RO+ CD4+ cells; while having 
      significantly lower secretion of interferon-gamma (IFN-gamma) by PBMC and 
      percentage of CD45RA+ CD4+ and CD28+ CD8+ cells. HIV infection in both 
      populations was associated with reduced IL-2, IL-4, IL-10, and IL-12 secretion, 
      number of CD28+ and CD45RA+ CD8+ cells, and increased number of HLA-DR+-CD3+, 
      CD4+, and CD8+ cells, and CD45RO+ CD8+ cells. Thus, infection with HIV-1 subtypes 
      B and C of studied Israelis and Ethiopians, respectively, results in a similar 
      immune activation profile at all stages of the infection when living in the same 
      environment, despite the striking different immune profile observed in the 
      HIV-negative Israeli and Ethiopian populations. Together with our previous 
      observations, this indicates that HIV subtype is not a major determinant in the 
      natural course of HIV infection.
FAU - Weisman, Z
AU  - Weisman Z
AD  - R. Ben-Ari Institute of Clinical Immunology, AIDS Center, Kaplan Medical Center, 
      Hebrew University Hadassah Medical School, Rehovot, Israel.
FAU - Kalinkovich, A
AU  - Kalinkovich A
FAU - Borkow, G
AU  - Borkow G
FAU - Stein, M
AU  - Stein M
FAU - Greenberg, Z
AU  - Greenberg Z
FAU - Bentwich, Z
AU  - Bentwich Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Cross-Sectional Studies
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Eosinophils/cytology
MH  - Ethiopia/ethnology
MH  - Female
MH  - HIV Infections/blood/*immunology/*virology
MH  - HIV Seronegativity/immunology
MH  - HIV-1/classification/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Israel
MH  - Leukocyte Count
MH  - Leukocytes, Mononuclear/immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Sexuality
MH  - T-Lymphocyte Subsets/immunology/metabolism
EDAT- 1999/06/09 00:00
MHDA- 1999/06/09 00:01
CRDT- 1999/06/09 00:00
PHST- 1999/06/09 00:00 [pubmed]
PHST- 1999/06/09 00:01 [medline]
PHST- 1999/06/09 00:00 [entrez]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 1999 Jun 1;21(2):157-63.