PMID- 10363175
OWN - NLM
STAT- MEDLINE
DCOM- 19990723
LR  - 20151119
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 13
IP  - 2
DP  - 1999 Mar-Apr
TI  - Increased level of serum hepatocyte growth factor/scatter factor in liver cancer 
      is associated with tumor metastasis.
PG  - 177-80
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) has been shown to play an 
      important role in tumor migration and metastasis. We therefore investigated the 
      relationship between HGF/SF expression and metastasis of human liver tumors. The 
      serum HGF/SF levels in 41 patients with primary hepatocellular carcinoma (HCC; 22 
      patients with metastasis, 19 patients without metastasis); 4 patients with benign 
      hepatic tumor, 4 patients with secondary hepatic carcinoma, and 12 healthy blood 
      donors, were measured by sandwich enzyme-linked immunosorbent assay (ELISA) in 
      this study. Our results show that liver tumor patients have significantly higher 
      serum levels of HGF/SF compared to healthy blood donors. However, there is no 
      difference between the serum HGF/SF levels in patients with primary HCC and 
      patients with secondary HCC or benign hepatic tumors. In addition, we measured 
      significantly higher levels of HGF/SF in serum from HCC patients with metastasis 
      compared to HCC patients without metastasis, indicating that the elevations in 
      serum HGF/SF level correlated positively with the tumor metastasis in human HCC. 
      These findings appear to suggest that HGF/SF may be a useful serological 
      biomarker for clinical diagnosis and follow-up of HCC metastasis, and suggest 
      that larger scale studies in patients with hepatomas are warranted.
FAU - Junbo, H
AU  - Junbo H
AD  - Department of Surgery, Tongji Hospital, Tongji Medical University, Hubei, P. R. 
      China.
FAU - Li, Q
AU  - Li Q
FAU - Zaide, W
AU  - Zaide W
FAU - Yunde, H
AU  - Yunde H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Biomarkers, Tumor)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Biomarkers, Tumor/blood
MH  - Carcinoma, Hepatocellular/*blood/pathology/secondary
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - Liver Neoplasms/*blood/pathology/secondary
EDAT- 1999/06/11 00:00
MHDA- 1999/06/11 00:01
CRDT- 1999/06/11 00:00
PHST- 1999/06/11 00:00 [pubmed]
PHST- 1999/06/11 00:01 [medline]
PHST- 1999/06/11 00:00 [entrez]
PST - ppublish
SO  - In Vivo. 1999 Mar-Apr;13(2):177-80.