PMID- 10364776
OWN - NLM
STAT- MEDLINE
DCOM- 20000120
LR  - 20191103
IS  - 0929-5305 (Print)
IS  - 0929-5305 (Linking)
VI  - 7
IP  - 2
DP  - 1999 Apr
TI  - Deep venous thrombosis: early discharge strategies and outpatient management.
PG  - 113-22
AB  - Conventional management of acute deep venous thrombosis (DVT) consists of 
      initiating continuous infusion intravenous unfractionated heparin (UFH) for 5 
      days in the hospital as well as warfarin. Low-molecular-weight heparins (LMWHs) 
      appear to confer similar protection against recurrent DVT compared with UFH but 
      exhibit prolonged bioavailability; increased ease of dosing, and fewer side 
      effects. The advent of LMWH has resulted in increased numbers of patients 
      undergoing initial management of acute DVT with only several days of 
      hospitalization. While 3-month follow-up studies with LMWH demonstrate similar 
      efficacy and safety to UFH, longer term experience with these new agents is 
      necessary to determine their optimal use and safety. We suggest a system for 
      triage in the initial management of DVT patients for: (1) complete outpatient 
      management with LMWH, or (2) short-term hospitalization for initiation of LMWH, 
      or (3) 5-day hospitalization for treatment with UFH. A review of DVT management 
      with LMWH and algorithms for each of these pathways are provided.
FAU - Baron, R M
AU  - Baron RM
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts 02115, USA.
FAU - Goldhaber, S Z
AU  - Goldhaber SZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Fibrinolytic Agents/administration & dosage/pharmacokinetics/*therapeutic use
MH  - Heparin/administration & dosage/pharmacokinetics/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/administration & 
      dosage/pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Infusions, Intravenous
MH  - *Outpatients
MH  - Practice Guidelines as Topic
MH  - Quality Assurance, Health Care
MH  - Triage
MH  - United States
MH  - United States Food and Drug Administration
MH  - Venous Thrombosis/*diagnosis/*drug therapy
MH  - Warfarin/therapeutic use
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - 10.1023/a:1008873201503 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 1999 Apr;7(2):113-22. doi: 10.1023/a:1008873201503.