PMID- 10365424
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20061115
IS  - 0340-1200 (Print)
IS  - 0340-1200 (Linking)
VI  - 80
IP  - 5
DP  - 1999 May
TI  - A joint interspike interval difference stochastic spike train analysis: detecting 
      local trends in the temporal firing patterns of single neurons.
PG  - 309-26
AB  - We introduce a stochastic spike train analysis method called joint interspike 
      interval difference (JISID) analysis. By design, this method detects changes in 
      firing interspike intervals (ISIs), called local trends, within a 4-spike pattern 
      in a spike train. This analysis classifies 4-spike patterns that have similar 
      incremental changes. It characterizes the higher-order serial dependence in spike 
      firing relative to changes in the firing history. Mathematically, this spike 
      train analysis describes the statistical joint distribution of consecutive 
      changes in ISIs, from which the serial dependence of the changes in higher-order 
      intervals can be determined. It is similar to the joint interspike interval 
      (JISI) analysis, except that the joint distribution of consecutive ISI 
      differences (ISIDs) is quantified. The graphical location of points in the JISID 
      scatter plot reveals the local trends in firing (i.e., monotonically increasing, 
      monotonically decreasing, or transitional firing). The trajectory of these points 
      in the serial-JISID plot traces the time evolution of these trends represented by 
      a 5-spike pattern, while points in the JISID scatter plot represent trends of a 
      4-spike pattern. We provide complete theoretical interpretations of the JISID 
      analysis. We also demonstrate that this method indeed identifies firing trends in 
      both simulated spike trains and spike trains recorded from cultured neurons.
FAU - Fitzurka, M A
AU  - Fitzurka MA
AD  - Department of Medical Physics, University of Wisconsin, Madison 53705, USA.
FAU - Tam, D C
AU  - Tam DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Biol Cybern
JT  - Biological cybernetics
JID - 7502533
SB  - IM
MH  - Animals
MH  - Biological Clocks
MH  - Cells, Cultured
MH  - Evoked Potentials
MH  - *Models, Neurological
MH  - Models, Statistical
MH  - Neurons/*physiology
MH  - Normal Distribution
MH  - Time Factors
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - 10.1007/s004220050528 [doi]
PST - ppublish
SO  - Biol Cybern. 1999 May;80(5):309-26. doi: 10.1007/s004220050528.