PMID- 10365570
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20191103
IS  - 1328-8067 (Print)
IS  - 1328-8067 (Linking)
VI  - 41
IP  - 3
DP  - 1999 Jun
TI  - Tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-3 in 
      Japanese healthy children and in Kawasaki disease and their clinical usefulness 
      in juvenile rheumatoid arthritis.
PG  - 239-45
AB  - BACKGROUND AND METHODS: To determine the clinical values of tissue inhibitor of 
      metalloproteinases-1 (TIMP-1) and matrix metalloproteinase-3 (MMP-3) in juvenile 
      rheumatoid arthritis (JRA), we measured serum levels of these enzymes with rapid 
      one-step sandwich enzyme immunoassay. Forty-one JRA patients, 48 normal healthy 
      children (NC) and 10 Kawasaki disease (KD) patients were investigated. RESULTS: 
      Serum TIMP-1 levels in NC corresponded to those in normal adults reported in the 
      literature, while MMP-3 levels were lower than those in healthy children and the 
      ratio of MMP-3/TIMP-1 decreased. The TIMP-1 levels in JRA and KD at the first 
      clinic examination were statistically higher than those in NC (P < 0.05) and 
      MMP-3 levels and MMP-3/TIMP-1 in JRA were significantly higher than those in NC 
      (P < 0.0001 and 0.0005, respectively) and KD (P < 0.001 and 0.0005, 
      respectively). In JRA, MMP-3 levels of patients with arthritis were statistically 
      higher than those of patients without arthritis (P < 0.05) and MMP-3 levels were 
      correlated with C-reactive protein (rs = 0.465, P < 0.05), while TIMP-1 did not 
      (rs = 0.340). There was a positive correlation between serum levels of MMP-3 and 
      TIMP-1 and prognosis (rs = 0.733, P < 0.05). CONCLUSION: In JRA, the serum MMP-3 
      level is a useful marker to evaluate joint damage, while serum TIMP-1 remains an 
      acute phase reactant.
FAU - Matsuyama, T
AU  - Matsuyama T
AD  - Department of Pediatrics, Kyorin University, School of Medicine Tokyo, Japan. 
      m-clinic@muf.biglobe.ne.jp
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Biomarkers)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Arthritis, Juvenile/classification/*enzymology/immunology
MH  - Biomarkers/*blood
MH  - Blood Sedimentation
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Mucocutaneous Lymph Node Syndrome/*enzymology/immunology
MH  - Prognosis
MH  - Protease Inhibitors/*blood
MH  - Reproducibility of Results
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - 10.1046/j.1442-200x.1999.01061.x [doi]
PST - ppublish
SO  - Pediatr Int. 1999 Jun;41(3):239-45. doi: 10.1046/j.1442-200x.1999.01061.x.