PMID- 10365804
OWN - NLM
STAT- MEDLINE
DCOM- 19990723
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 30
IP  - 5
DP  - 1999 May
TI  - HLA antigens in patients with interferon-alpha-induced autoimmune thyroid 
      disorders in chronic hepatitis C.
PG  - 794-800
AB  - BACKGROUND/AIMS: To determine the immunological predisposition to autoimmune 
      thyroid disorders induced by interferon-alpha therapy, human leukocyte antigen 
      (HLA) was analyzed in patients with chronic hepatitis C who developed autoimmune 
      thyroid disorders during or after treatment with interferon-alpha. METHODS: Four 
      hundred and thirty-nine patients with chronic hepatitis C (278 males and 161 
      females, aged 20-73 years) were treated with interferon-alpha (natural-alpha, 
      169; alpha-2a, 82; alpha-2b, 188) for 24 weeks. RESULTS: Seventeen of 439 (3.9%) 
      patients developed symptomatic autoimmune thyroid disorders; these included nine 
      cases of hyperthyroidism and eight cases of hypothyroidism. The incidence of 
      HLA-A2, B46 and Cw7 increased in patients with interferon-alpha-induced 
      autoimmune thyroid disorders. Especially, the incidence of HLA-A2 (15/17; 88.2%) 
      was significantly higher than that observed in the general population in Japan 
      (corrected p-value (p(c)): p(c)<0.003). The odds ratios for the relative risk of 
      the autoimmune thyroid disorders were A2, 10.6 [95% confidence interval, 
      2.4-46.5]; B46, 4.8 [1.6-14.0]; and Cw7, 3.0 [1.1-7.9]. CONCLUSIONS: Our study 
      revealed that HLA-A2 is highly linked to the autoimmune thyroid disorders induced 
      by interferon-alpha-therapy in patients with chronic hepatitis C.
FAU - Kakizaki, S
AU  - Kakizaki S
AD  - The First Department of Internal Medicine, Gunma University School of Medicine, 
      Maebashi, Japan. kakizaki@news.sb.gunma-u.ac.jp
FAU - Takagi, H
AU  - Takagi H
FAU - Murakami, M
AU  - Murakami M
FAU - Takayama, H
AU  - Takayama H
FAU - Mori, M
AU  - Mori M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiviral Agents/*adverse effects
MH  - Female
MH  - Genes, MHC Class I
MH  - HLA-D Antigens/*blood
MH  - Hepatitis C, Chronic/genetics/*immunology/*therapy
MH  - Histocompatibility Antigens Class I/*blood
MH  - Humans
MH  - Interferon alpha-2
MH  - Interferon-alpha/*adverse effects
MH  - *Major Histocompatibility Complex
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Recombinant Proteins
MH  - Thyroiditis, Autoimmune/*chemically induced/genetics/*immunology
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - S0168-8278(99)80131-7 [pii]
AID - 10.1016/s0168-8278(99)80131-7 [doi]
PST - ppublish
SO  - J Hepatol. 1999 May;30(5):794-800. doi: 10.1016/s0168-8278(99)80131-7.