PMID- 10366412
OWN - NLM
STAT- MEDLINE
DCOM- 19990728
LR  - 20190905
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 140
IP  - 6
DP  - 1999 Jun
TI  - Somatic MEN1 gene mutation does not contribute significantly to sporadic 
      pituitary tumorigenesis.
PG  - 573-6
AB  - Pituitary adenomas are a common manifestation of multiple endocrine neoplasia 
      type 1 (MEN1) but most of them occur sporadically. There are only a few well 
      defined genetic abnormalities known to occur in these sporadic tumours. The MEN1 
      gene located on 11q13 has recently been cloned and allelic deletion and mutation 
      analysis studies have implicated the MEN1 gene in a significant fraction of the 
      sporadic counterparts of typical MEN1 neoplasms (parathyroid tumours, insulinomas 
      and gastrinomas). To determine if MEN1 gene inactivation is also involved in the 
      development of sporadic pituitary adenomas, allelic deletions of chromosome 11q13 
      and MEN1 gene mutations and polymorphisms were assessed in 35 sporadic tumours of 
      the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 
      TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be 
      heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a 
      flanking gene polymorphism (6 cases). The remaining tumours were not informative. 
      No mutations were found in any tumour except in one prolactinoma which was 
      homozygous or hemizygous for a mutation (1-117 C-->T) in a region close to the 
      promoter. Unfortunately, blood or normal tissue was not available in this case. 
      Our data show that somatic MEN1 mutations do not contribute significantly to 
      tumorigenesis of sporadic pituitary adenomas and suggest that mutation of other 
      genes are likely to contribute to the pathogenesis of these tumours.
FAU - Poncin, J
AU  - Poncin J
AD  - Department of Medical Genetics, University Hospital, University of Liege, 4000 
      Liege, Belgium.
FAU - Stevenaert, A
AU  - Stevenaert A
FAU - Beckers, A
AU  - Beckers A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
SB  - IM
MH  - Adenoma/*etiology/genetics
MH  - Cryopreservation
MH  - Genetic Testing
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - *Mutation
MH  - Pituitary Gland, Anterior
MH  - Pituitary Neoplasms/*etiology/genetics
MH  - Polymorphism, Genetic
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - 1400573 [pii]
AID - 10.1530/eje.0.1400573 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1999 Jun;140(6):573-6. doi: 10.1530/eje.0.1400573.