PMID- 10367358
OWN - NLM
STAT- MEDLINE
DCOM- 19990709
LR  - 20061115
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 30
IP  - 2-3
DP  - 1999 Mar-Jun
TI  - Enterotoxigenic Escherichia coli (ETEC) in farm animals.
PG  - 259-84
AB  - Animal diseases due to enterotoxigenic Escherichia coli (ETEC) typically appear 
      as severe watery diarrhoea during the first few days of life (also a few days 
      after weaning in pigs). ETEC adhere to the small intestinal microvilli without 
      inducing morphological lesions and produce enterotoxins acting locally on 
      enterocytes. This action results in the hypersecretion (of water and 
      electrolytes) and reduced absorption. Adhesins and toxins are the two prominent 
      virulence attributes of ETEC and the level of knowledge of these factors 
      determines the chances for successful prevention and therapy of the disease. For 
      animal ETEC the most common adhesins are the fimbriae (pili) on the surface: 
      F4(K88), F5(K99), F6(987P), F41, F42, F165, F17 and F18. Enterotoxins 
      (extracellular proteins or peptides) of animal ETEC are classified as heat-labile 
      (LT) and heat-stable (ST) enterotoxins with further subdivisions (LTh-I, LTp-I, 
      LTIIa, LTIIb, STaH, STaP, STb) according to antigenic and biological differences. 
      Fimbriae and LT enterotoxins are made up of large molecular weight proteins which 
      facilitate their utilisation in vaccines and their detection using 
      immunodiagnostic systems. The adhesive fimbriae and enterotoxins of animal ETEC 
      are plasmid determined (except F41 and F17). Virulence gene probes (DNA 
      hybridisation, PCR) are specific and sensitive diagnostic and epidemiologic tools 
      for the detection of ETEC. Based on genetic typing, the ETEC, in spite of limited 
      serogroups, seem to represent a population of E. coli with a diverse genetic 
      background.
FAU - Nagy, B
AU  - Nagy B
AD  - Veterinary Medical Research Institute of the Hungarian Academy of Sciences, 
      Budapest. bnagy@novell.vmri.hu
FAU - Fekete, P Z
AU  - Fekete PZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
RN  - 0 (Enterotoxins)
SB  - IM
MH  - Animals
MH  - Animals, Domestic
MH  - Diarrhea/physiopathology/veterinary
MH  - Enterotoxins/*biosynthesis
MH  - Escherichia coli/classification/*pathogenicity
MH  - Escherichia coli Infections/microbiology/physiopathology/*veterinary
MH  - Swine
MH  - Swine Diseases/microbiology/physiopathology
MH  - Virulence
RF  - 129
EDAT- 1999/06/15 00:00
MHDA- 1999/06/15 00:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 1999/06/15 00:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
PST - ppublish
SO  - Vet Res. 1999 Mar-Jun;30(2-3):259-84.