PMID- 10368635
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 2A
DP  - 1999 Mar-Apr
TI  - Detection of chromosome 11q13 amplification in head and neck cancer using 
      fluorescence in situ hybridization.
PG  - 925-31
AB  - BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) remains a cancer with 
      one of the lowest five-year survival rates. Despite a better understanding of the 
      disease and recent advances in diagnosis and treatment, survival rates for HNSCC 
      patients have not improved. Chromosomal abnormalities are common in HNSCC, and 
      aberrations of chromosome 11q13 have been correlated with a poor prognosis. 
      MATERIALS AND METHODS: In this study we utilized fluorescence in situ 
      hybridization (FISH) to determine the incidence of 11q13 amplification in twenty 
      primary HNSCC tumors. INT-2 was used as the 11q13 probe, and 9 and 11 centromeric 
      probes were used as controls. RESULTS: Polysomy, greater than two copies of 
      chromosome 11, was found in 2 of 20 tumors. INT2 (11q13) amplification was found 
      in 3 other tumors. CONCLUSIONS: These preliminary studies indicate tht analysis 
      of a larger sample of tumors using FISH may yield important diagnostic and 
      prognostic information about head and neck tumors.
FAU - Wang, M B
AU  - Wang MB
AD  - Division of Head and Neck Surgery, UCLA School of Medicine 90073, USA. 
      mbwang@ucla.edu
FAU - Alavi, S
AU  - Alavi S
FAU - Engstrom, M
AU  - Engstrom M
FAU - Lee, J
AU  - Lee J
FAU - Namazie, A
AU  - Namazie A
FAU - Moatamed, F
AU  - Moatamed F
FAU - Srivatsan, E S
AU  - Srivatsan ES
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - Head and Neck Neoplasms/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
EDAT- 1999/06/16 00:00
MHDA- 1999/06/16 00:01
CRDT- 1999/06/16 00:00
PHST- 1999/06/16 00:00 [pubmed]
PHST- 1999/06/16 00:01 [medline]
PHST- 1999/06/16 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Mar-Apr;19(2A):925-31.