PMID- 10368638
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 2A
DP  - 1999 Mar-Apr
TI  - Detection of p53 protein accumulation in sputum and lung adenocarcinoma 
      associated with indoor exposure to unvented coal smoke in China.
PG  - 951-8
AB  - Lung cancer in Xuan Wei (XW), China has been linked to exposure to unvented coal 
      smoke and adenocarcinoma, especially bronchioloalveolar carcinoma, is most 
      common. p53 mutations occur commonly in lung cancers and usually generate 
      detectable levels of p53 protein accumulation. Sputum is noninvasive to collect 
      and ideal for screening p53 abnormalities. p53 protein accumulation was detected 
      by immunohistochemistry in lung tumors and sputa from XW lung cancer patients to 
      determine (1) the role of p53 in lung pathogenesis, and (2) feasibility of 
      detecting p53 protein accumulation in sputum, p53 protein accumulation was 
      detected in 73% (22/30) of lung adenocarcinomas from XW females exposed to coal 
      emissions and significantly higher than the control cases (33%, p < 0.05). In 
      sputum, we detected p53 overexpression in tumor cells in 54% (13/24) of XW cases 
      and also in dysplastic cells (50% or 4/8). These findings suggest that p53 
      abnormalities is important in XW lung cancer etiology.
FAU - Mumford, J L
AU  - Mumford JL
AD  - U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
FAU - Tian, D
AU  - Tian D
FAU - Younes, M
AU  - Younes M
FAU - Hu, F
AU  - Hu F
FAU - Lan, Q
AU  - Lan Q
FAU - Ostrowski, M L
AU  - Ostrowski ML
FAU - He, X
AU  - He X
FAU - Feng, Z
AU  - Feng Z
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Coal)
RN  - 0 (Smoke)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adenocarcinoma/chemistry/*etiology
MH  - Adult
MH  - Aged
MH  - Air Pollution, Indoor/*adverse effects
MH  - China
MH  - *Coal
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/chemistry/*etiology
MH  - Male
MH  - Middle Aged
MH  - Smoke/*adverse effects
MH  - Sputum/*chemistry
MH  - Tumor Suppressor Protein p53/*analysis
EDAT- 1999/06/16 00:00
MHDA- 1999/06/16 00:01
CRDT- 1999/06/16 00:00
PHST- 1999/06/16 00:00 [pubmed]
PHST- 1999/06/16 00:01 [medline]
PHST- 1999/06/16 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Mar-Apr;19(2A):951-8.