PMID- 1036960
OWN - NLM
STAT- MEDLINE
DCOM- 19770224
LR  - 20131121
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 26
IP  - 8
DP  - 1976
TI  - Antagonism of maximal metrazol seizures in rats and its relevance to an 
      experimental classification of antiepileptic drugs.
PG  - 1592-603
AB  - The antagonism of various components of maximal Metrazol-seizures (MMS) (i.e. 
      tonic hindpaw extension, tonic backward extension of the forepaws, generalized 
      clonic seizures and tremors), ataxia and loss of righting reflex-activity have 
      been studied in a standardized procedure comparing 41 antiepileptics and related 
      compounds. Appropriate analyses (Cluster Analysis and Principal Component 
      Analysis) resulted in the distinction of seven clusters which could be considered 
      along two continua. A first continuum is characterized by a progressive 
      strengthening of loss of righting reflex-inducing properties, a decreasing 
      dissociation of ataxia and loss of righting reflex and the disappearance of a 
      selective anticonvulsant effect. The second continuum is characterized by an 
      increasing relative potency of ataxia-inducing properties, an increasing 
      dissociation of ataxia and loss of righting reflex and a decreasing antagonism of 
      tremors. Three main types of anticonvulsants could be defined: drugs with a 
      complete anti-MMS effect antagonizing both clonic and tonic seizures; drugs 
      selectively abolishing tonic seizures, i.e., tonic extension of hind- and 
      forepaws; and drugs exclusively blocking tonic hind-paw extension. The 
      neurological and clinical significance of these different types of anticonvulsant 
      activity has been discussed. Finally, the described modification of the maximal 
      Metrazol-seizures test is proposed for routine screening purposes.
FAU - Desmedt, L K
AU  - Desmedt LK
FAU - Niemegeers, C J
AU  - Niemegeers CJ
FAU - Lewi, P J
AU  - Lewi PJ
FAU - Janssen, P A
AU  - Janssen PA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Anticonvulsants)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*classification/pharmacology
MH  - Ataxia/chemically induced
MH  - Drug Evaluation, Preclinical/methods
MH  - Female
MH  - Pentylenetetrazole/*antagonists & inhibitors
MH  - Posture
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex/drug effects
MH  - Seizures/chemically induced
MH  - Tremor/chemically induced
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1976;26(8):1592-603.