PMID- 103706
OWN - NLM
STAT- MEDLINE
DCOM- 19790313
LR  - 20190918
IS  - 0147-6513 (Print)
IS  - 0147-6513 (Linking)
VI  - 2
IP  - 2
DP  - 1978 Sep
TI  - Environmental chemical-induced immune dysfunction.
PG  - 173-98
AB  - Antibody formation, endotoxin sensitivity, and resistance to a challenge malarial 
      infection were evaluated in mice fed a diet containing polychlorinated biphenyl 
      (PCB) (Aroclor 1242) or hexachlorobenzene (HCB). Antibody synthesis to the 
      antigen sheep RBC (SRBC) was significantly depressed in the PCB- and HCB-treated 
      (167 ppm) animals as evidenced by the fact that control mice elicited an 
      approximate twofold increase in antibody formation over the chemical-treated 
      mice. Serum IgA concentrations in the PCB- and HCB-treated mice were consistently 
      40--80 mg/dl lower than control values. Gram-negative endotoxin (Salmonella 
      typhosa) sensitivity in PCB- and HCB-treated mice was increased 5.2- and 32-fold, 
      respectively, following the dietary administration of 167 ppm of Aroclor 1242 or 
      HCB for 6 weeks. An endotoxin hypersusceptibility was also noted at 3 weeks after 
      dietary administration. Decreased resistance to a malaria challenge was also 
      demonstrated in the xenobiotic-treated mice. A 20% decrease in mean survival time 
      of mice fed Aroclor 1242 for 3 to 6 weeks and inoculated with Plasmodium berghei 
      (NYU-2) was observed. Infected mice which had received HCB for 3 or 6 weeks 
      manifested reductions in mean survival time of 24 and 31%, respectively. The data 
      indicated that environmental chemical contaminants impair host resistance and, 
      since no concomitant histopathological alterations were observed in the treated 
      mice, the evaluation of immune parameters may possibly be a sensitive indicator 
      of toxicity.
FAU - Loose, L D
AU  - Loose LD
FAU - Pittman, K A
AU  - Pittman KA
FAU - Benitz, K F
AU  - Benitz KF
FAU - Silkworth, J B
AU  - Silkworth JB
FAU - Mueller, W
AU  - Mueller W
FAU - Coulston, F
AU  - Coulston F
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Chlorobenzenes)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Chlorobenzenes/*pharmacology
MH  - Hexachlorobenzene/*pharmacology
MH  - Immunity/*drug effects
MH  - Liver/pathology
MH  - Lung/pathology
MH  - Lymph Nodes/pathology
MH  - Malaria/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phagocytosis/drug effects
MH  - Polychlorinated Biphenyls/*pharmacology
MH  - Spleen/pathology
MH  - Thymus Gland/pathology
EDAT- 1978/09/01 00:00
MHDA- 1978/09/01 00:01
CRDT- 1978/09/01 00:00
PHST- 1978/09/01 00:00 [pubmed]
PHST- 1978/09/01 00:01 [medline]
PHST- 1978/09/01 00:00 [entrez]
AID - 0147-6513(78)90008-8 [pii]
AID - 10.1016/0147-6513(78)90008-8 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 1978 Sep;2(2):173-98. doi: 10.1016/0147-6513(78)90008-8.