PMID- 10370804
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20190831
IS  - 0929-693X (Print)
IS  - 0929-693X (Linking)
VI  - 6
IP  - 5
DP  - 1999 May
TI  - [The value of procalcitonin in neonatal infections].
PG  - 503-9
AB  - The value of procalcitonin (PCT) measurement is not presently completely assessed 
      for the diagnosis of neonatal infections. PATIENTS AND METHODS: This parameter 
      was assessed in a prospective study in the neonatal intensive care unit of 
      Clermont-Ferrand Hospital (France) in comparison to C-reactive protein. All 
      newborn infants admitted before 24 h of life (day 0) in the neonatal intensive 
      care unit were included in the study. Newborns (102) were assigned to one of four 
      groups: group 1: non-infected newborns (n = 41); group 2: possibly infected 
      newborns (n = 33); group 3: probably infected newborns (n = 10); group 4: 
      confirmed infections (n = 18 bacterial or fungal infections). C-reactive protein 
      and PCT were determined in the sera at D0, D1, D3 and D8. We determined the 
      optimal cutoff value of PCT using the Receiver Operating Characteristic curves 
      (R.O.C.). RESULTS: The cutoff value is 1.5 ng/mL at D0 and 10 ng/mL at D1. PCT 
      cutoff value is significantly higher at D1 because of a significant PCT peak on 
      the first day of life independent of any infectious stimulus. Our study shows 
      that at D0 and D1 infected newborn infants had significantly higher mean PCT and 
      C-reactive protein values than non infected newborn infants. C-reactive protein 
      has a better specificity but PCT has better sensitivity and negative predictive 
      value. CONCLUSION: PCT seems to be an interesting marker of neonatal infections 
      especially during the first 24 h of life even though the mechanism of PCT 
      synthesis remains unclear.
FAU - Maire, F
AU  - Maire F
AD  - Service de biochimie et de biologie moleculaire, hopital Gabriel-Montpied, 
      Clermont-Ferrand, France.
FAU - Heraud, M C
AU  - Heraud MC
FAU - Loriette, Y
AU  - Loriette Y
FAU - Normand, B
AU  - Normand B
FAU - Begue, R J
AU  - Begue RJ
FAU - Labbe, A
AU  - Labbe A
LA  - fre
PT  - Comparative Study
PT  - Journal Article
TT  - Interet de la procalcitonine dans les infections neonatales.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
RN  - 0 (CALCA protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Protein Precursors)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Bacterial Infections/*blood
MH  - C-Reactive Protein/analysis
MH  - Calcitonin/*blood
MH  - Calcitonin Gene-Related Peptide
MH  - Female
MH  - Follow-Up Studies
MH  - Glycoproteins/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal
MH  - Male
MH  - Mycoses/*blood
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Protein Precursors/*blood
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 1999/06/17 10:00
MHDA- 2000/05/05 09:00
CRDT- 1999/06/17 10:00
PHST- 1999/06/17 10:00 [pubmed]
PHST- 2000/05/05 09:00 [medline]
PHST- 1999/06/17 10:00 [entrez]
AID - S0929693X99805557 [pii]
AID - 10.1016/s0929-693x(99)80555-7 [doi]
PST - ppublish
SO  - Arch Pediatr. 1999 May;6(5):503-9. doi: 10.1016/s0929-693x(99)80555-7.